Year 2008 / Volume 100 / Number 2
Original
Assessing the use of proton pump inhibitors in an internal medicine department

pp. 76-81

Martín-Echevarría, E. / Pereira Juliá, A. / Torralba, M. / Arriola Pereda, G. / Martín Dávila, P. / Mateos, J. / Rodríguez Zapata, M.

Abstract
Introduction: proton pump inhibitors (PPIs) block the H+/K+ ATPase enzyme in gastric wall cells, leading to an inhibition of both baseline and stimulated acid secretion. Appropriate indications include: Gastroesophageal reflux, acute upper gastrointestinal bleeding, erosive gastritis or esophagitis, dyspepsia, NSAID-related gastropathy, and stress ulcer prophylaxis in high risk patients. The aims of this study were to review the current indications of PPIs, and to evaluate their use in Guadalajara’s University Hospital.

Material and methods: a transversal, analytic, randomized study was carried out during 2003 in our internal medicine department. A total of 208 medical records for 832 patients receiving PPIs were reviewed (25%). Mean age was 67 years (range: 16-92), 46.2% were females, and most frequent conditions were HBP, COPD, and DM.

Results: 34.6% of patients took PPIs before admission, their use being inappropriate in 68.1% of them. Among hospitalized patients 73.03% used PPIs inappropriately, and most of them had no such indication at discharge.

Conclusions: results are in accordance with the literature, with a high frequency of incorrect PPI use; a more accurate use of PPIs is to be recommended to avoid side effects and drug interactions, and to provide a more efficient medical care.
New comment
Comments
No comments for this article
Related articles
Citation tools
Martín-Echevarría, E. / Pereira Juliá, A. / Torralba, M. / Arriola Pereda, G. / Martín Dávila, P. / Mateos, J. / Rodríguez Zapata, M.. Assessing the use of proton pump inhibitors in an internal medicine department. 76-81


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 188 visits.
This article has been downloaded 72 times.
Share
This article has been rated by 1 readers.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2025 y Creative Commons. The Spanish Journal of Gastroenterology