Year 2019 / Volume 111 / Number 11
Letter
A positive clinical experience of a long-term treatment pattern with leukocyte apheresis and Adacolumn in ulcerative proctitis

889

DOI: 10.17235/reed.2019.6073/2018

Elena Borrego García, María Peña Ortega, Alicia Martín-Lagos Maldonado,

Abstract
Ulcerative proctitis (UP) is often involved in the diagnosis of inflammatory bowel disease (IBD). The increase of leukocytes and pro-inflammatory factors in peripheral blood and in the active forms, as well as the infiltration of neutrophils and monocytes/macrophages in the intestinal mucosa is known to occur in this entity. This infiltration of cells damages the mucosa due to the liberation of proteases, oxidation radicals and cytokines, among others. Apheresis techniques such as leukocyte apheresis may be used among the different therapeutic options such as steroids, sulfasalazine, 5-aminosalicylic, tacrolimus, azathioprine, cyclosporine, mycophenolate and biological agents.
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Borrego García E, Peña Ortega M, Martín-Lagos Maldonado A. A positive clinical experience of a long-term treatment pattern with leukocyte apheresis and Adacolumn in ulcerative proctitis. 6073/2018


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Publication history

Received: 28/11/2018

Accepted: 09/02/2019

Online First: 02/10/2019

Published: 07/11/2019

Article Online First time: 308 days

Article editing time: 344 days


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