Year 2022 / Volume 114 / Number 2
Original
Thiopurine adherence: a high prevalence with low impact on UC outcomes

76-82

DOI: 10.17235/reed.2021.7630/2020

Concepción Gómez-Medina, María Capilla-Lozano, María Pilar Ballester-Ferré, David Martí-Aguado, Ana Crespo, Marta Maia Bosca-Watts, Pablo Navarro-Cortés, Rosario Antón, Isabel Pascual-Moreno, Joan Tosca Cuquerella, Miguel Mínguez Pérez,

Abstract
Introduction: thiopurines are used as maintenance therapy in patients with ulcerative colitis (UC). There are contradictory results regarding the relationship between adherence to treatment and risk of relapse. Objectives: to quantify and evaluate the trends in thiopurine prescription rates, and to determine the impact and risk factors of non-adherence. Methods: analytical, observational, retrospective study of UC patients taking thiopurines included in the ENEIDA single-center registry from October 2017 to October 2019. Adult patients in clinical remission at the beginning of the study on thiopurines maintenance treatment for at least 6 months before recruitment were included. Adherence was evaluated with an electronic pharmaceutical prescription system. Adherence was considered when 80 % or more of the prescribed medication was dispensed at the pharmacy. Kaplan-Meier curves and a regression model were used to examine year-to-year treatment dispensation, and to identify factors associated with non-adherence. Results: a total of 41 patients were included, of whom 71 % were males with a mean age of 44 (14), and 26.8 % were concomitantly managed with biological therapy. Overall, 22 % were non-adherent to thiopurines. No predictive factors of non-adherence were identified. Adherence rate did not correlate with disease activity during two years of follow-up (OR 1.6; 95 % CI = 0.3-9.1). Left-sided colitis and concomitant biological treatment were related with disease relapse (p ≤ 0.01). Conclusion: adherence to thiopurines in UC patients is high (78 %). Non-adherence is not related to clinical or pharmacological factors. Adherence rate was not associated with disease activity.
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Gómez-Medina C, Capilla-Lozano M, Ballester-Ferré M, Martí-Aguado D, Crespo A, Bosca-Watts M, et all. Thiopurine adherence: a high prevalence with low impact on UC outcomes . 7630/2020


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Publication history

Received: 02/11/2020

Accepted: 08/03/2021

Online First: 18/03/2021

Published: 07/02/2022

Article revision time: 120 days

Article Online First time: 136 days

Article editing time: 462 days


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