Year 2016 / Volume 108 / Number 12
Original
Spasmolytic effect of Jasonia glutinosa on rodent intestine

785-789

DOI: 10.17235/reed.2016.4327/2016

Marta Castro, Mariano Ramón Giménez, Francisco Les, Lorena Trejo, Miguel Ángel Plaza, Víctor López, María Divina Murillo, Marta Sofia Valero,

Abstract
Introduction: Jasonia glutinosa is an endemic plant species of the Iberian Peninsula and Southern France traditionally used in infusions as a spasmolytic; this plant is also known as “té de roca” (rock tea) but there is no scientific evidence about the effects of this plant. Aim: To evaluate the spasmolytic effect of rock tea. Methods: We have studied the in vitro effect of a rock tea extract on rat duodenum spontaneous contractions and the in vivo effect on mice gastrointestinal transit. Results: Rock tea extract reduced the spontaneous contractions of rat duodenal smooth muscle, inhibited KCl-induced contractions and blocked the contractions invoked by both extracellular Ca2+ and the agonist of L-type calcium channels Bay K8644. This inhibitory effect was similar to the one observed after the addition of the antagonist of L-type calcium channels verapamil. Rock tea did not modify gastrointestinal transit in healthy mice. However, after the treatment with dextran sulfate sodium, an inducer of colitis, rock tea extract reverted the increase in the gastrointestinal transit associated with this treatment. Conclusion: Rock tea extract relaxed duodenal smooth muscle via L-type calcium channels and normalized gastrointestinal transit in a model of colitis. These results may validate the traditional use of Jasonia glutinosa in patients with gastrointestinal alterations. Thus, rock tea may be used as a spasmolytic agent to treat gastrointestinal disorders.
Share Button
New comment
Comments
No comments for this article
References
1. Longstreth GF, Thompson WG, Chey WD, et al. Functional bowel disorders. Gastroenterology 2006; 130(Supl. 5): 1480-91.
2. Kishimoto Y, Tani M, Kondo K. Pleiotropic preventive effects of dietary polyphenols in cardiovascular diseases. Eur J Clin Nutr 2013; 67: 532-35.
3. Lisowska A, Stawińska-Witoszyńska B, Bajerska J, et al. Green tea influences intestinal assimilation of lipids in humans: a pilot study. Eur Rev Med Pharmacol Sci 2015; 19(Supl. 2): 209-14.
4. Yang CS, Hong J. Prevention of chronic diseases by tea: possible mechanisms and human relevance. Annu Rev Nutr 2013; 33: 161-81.
5. Yang CS, Chen G, Wu Q. Recent scientific studies of a traditional Chinese medicine, tea, on prevention of chronic diseases. J Tradit Complement Med 2014; 4(Supl. 1): 17-23.
6. Pardo de Santayana, M, Morales R. Consideraciones sobre el género Jasonia (Compositae, Inulae): sistemática y usos. Acta Botánica Malacitana 2004; 29: 221-32.
7. Alarcon R, Pardo de Santayana M, Priestley C, et al. Medicinal and local food plants in the south of Alava (Basque Country, Spain). Journal of Ethnopharmacology 2015; 176: 207-24.
8. Valero MS, Berzosa C, Langa E, et al. Jasonia glutinosa D.C (Rock tea): botanical, phytochemical and pharmacological aspects. Bol Latinoam Caribe Plant Med Aromat 2013; 12(Supl. 6): 543-57.
9. Valero MS, Oliván-Viguera A, Garrido I, et al. Rock Tea extract (Jasonia glutinosa) relaxes rat aortic smooth muscle by inhibition of L-type Ca2+ channels. J Physiol Biochem 2015; 71(Supl. 4): 785-93.
10. Gonzalez Romero MA, Villaescusa Castillo L, Diaz Lanza AM, et al. Volatile composition of Jasonia glutinosa D. C. Z Naturforsch C 2003; 58: 804-06.
11. Rubio B, Villaescusa L, Diaz AM, Fernandez L, et al. Flavonol glycosides from Scolymus hispanicus and Jasonia glutinosa. Planta Med 1995; 61: 583.
12. Sanchez-Martinezn R, Villaescusa-Castillo L, Bernabe M, et al. Two new eudesmane alcohols from Jasonia glutinosa. Z Naturforsch C 2000; 55: 693-96.
13. Valero MS, Fagundes DS, Grasa L, et al. Contractile effect of tachykinins on rabbit small intestine. Acta Pharmacol Sin 2011; 32(Supl. 4): 487-94.
14. Fagundes DS, Grasa L, Arruebo MP, et al. Ca2+-activated K+ channels involved in duodenal dismotility induced by ethanol. Alcohol Alcohol 2007, 42(Supl. 4): 291-95.
15. Brading AF. How do drugs initiate contraction in smooth muscles?. Trends in Pharmacological Sciences 1981; 2: 261-65.
16. Grasa L, Rebollar E, Arruebo MP, et al. The role of Ca2+ in the contractility of rabbit small intestine in vitro. J Physiol and Pharmacol 2004; 55: 639-50.
17. Perše M, Cerar A. Dextran sodium sulphate colitis mouse model: traps and tricks. J Biomed Biotechnol 2012, 2012:718617.
18. Gilani AH, Shah AJ, Ghayur MN, et al. Pharmacological basis of the use of turmeric in gastrointestinal and respiratory disorders. Life Sciences 2005; 76: 13089-105.
19. Brunton LL. Agents affecting gastrointestinal water flux and motility, emesis and antiemetics, bile acids and pancreatic enzymes. En: Gilman AG, Hardman JG, Limbird LE, Molinoff PB, Ruddon RW (Eds), Goodman &Gilman´s: The Pharmacological Basis of Therapeutics. McGraw-Hill, New York, 1996. p. 917-36.
20. Formica JV, Regelson W. Review of the biology of quercetin and related bioflavonoids. Food Chem Toxicol 1995; 33(Supl. 12): 1061-80.
21. Gharzouli K, Holzer P. Inhibition of guinea pig intestinal peristalsis by the flavonoids quercetin, naringenin, apigenin and genistein. Pharmacology 2004; 70(Supl. 1): 5-14.
Related articles

Digestive Diseases Image

Spontaneous duodenal wall hematoma

DOI: 10.17235/reed.2023.9793/2023

Letter

Duodenal stenosis surgical treatment in Crohn’s disease

DOI: 10.17235/reed.2023.9521/2023

Digestive Diseases Image

A case of duodenal-type follicular lymphoma

DOI: 10.17235/reed.2021.8233/2021

Digestive Diseases Image

Endoscopic resection of a duodenal neuroendocrine tumor

DOI: 10.17235/reed.2021.8232/2021

Digestive Diseases Image

Duodenal diverticulum causing obstructive jaundice – Lemmel’s syndrome

DOI: 10.17235/reed.2020.7516/2020

Digestive Diseases Image

A rare solitary duodenum plasmacytoma

DOI: 10.17235/reed.2019.6090/2018

Citation tools
Castro M, Ramón Giménez M, Les F, Trejo L, Plaza M, López V, et all. Spasmolytic effect of Jasonia glutinosa on rodent intestine. 4327/2016


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1021 visits.
This article has been downloaded 94 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 16/03/2016

Accepted: 01/09/2016

Online First: 02/11/2016

Published: 30/11/2016

Article revision time: 164 days

Article Online First time: 231 days

Article editing time: 259 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology