Year 2023 / Volume 115 / Number 12
Letter
Large cell neuroendocrine carcinoma at the esophagogastric junction. An extremely rare entity

719-720

DOI: 10.17235/reed.2023.9505/2023

Manuel García-Redondo, José Ruiz Pardo, Pedro Antonio Sánchez Fuentes, Elisabet Vidaña Márquez, Ricardo Belda Lozano, Álvaro Pérez-Rodríguez, Íñigo Gorostiaga, Ángel Reina Duarte,

Abstract
We present the third case described to date of large cell neuroendocrine carcinoma located at the esophagogastric junction (LCNEC). Esophageal neuroendocrine tumours account for 0.03-0.05% of all malignant esophageal tumours. Within oesophageal NETs, LCNEC accounts for 1% of esophageal NETs. This tumour type is characterised by elevated levels of certain markers: synaptophysin, chromogranin A and CD56. In fact, 100% of patients will have chromogranin or synaptophysin, or at least one of these three markers. In turn, 78% will have lymphovascular invasion and 26% will have perineural invasion. Only 11% of patients will have stage I-II, which implies an aggressive course and worse prognosis.
Share Button
New comment
Comments
No comments for this article
References
1. Mastracci L, Rindi G, Grillo F, et al. Neuroendocrine neoplasms of the esophagus and stomach. Pathologica. 2021;113:5–11. DOI: 10.32074/1591-951X-229
2. Ichimata S, Aoyagi D, Takehana T, et al. A case of large cell neuroendocrine carcinoma exhibiting rhabdoid features in the esophagogastric junction: A case of neuroendocrine carcinoma exhibiting rhabdoid. Pathol Int. 2019;69:481–7. DOI: 10.1111/pin.12807
3. Shia J, Tang LH, Weiser MR, et al. Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity? Am J Surg Pathol. 2008;32:719–31. DOI: 10.1097/PAS.0b013e318159371c
4. Fucuchi M, Sakurai S, Tsukagoshi R, et al. A case of large cell neuroendocrine carcinoma of the esophagogastric junction. Esophagus. 2015;12:295–9. DOI: 10.1007/s10388-014-0443-7
5. Belvis Jiménez M, Guerra Veloz MF, Rodríguez-Téllez M. An esophageal neuroendocrine tumor in a Barrett's esophagus successfully treated with endoscopic resection. Rev Esp Enferm Dig. 2020;112:885-6. DOI: 10.17235/reed.2020.6907/2020
Citation tools
García-Redondo M, Ruiz Pardo J, Sánchez Fuentes P, Vidaña Márquez E, Belda Lozano R, Pérez-Rodríguez Á, et all. Large cell neuroendocrine carcinoma at the esophagogastric junction. An extremely rare entity. 9505/2023


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 859 visits.
This article has been downloaded 76 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 31/01/2023

Accepted: 10/02/2023

Online First: 22/02/2023

Published: 12/12/2023

Article Online First time: 22 days

Article editing time: 315 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology