Year 2023 / Volume 115 / Number 9
Letter
Diagnosis of a cystic pancreatic neuroendocrine tumor: is cystic fluid chromogranin A useful?

526-527

DOI: 10.17235/reed.2022.9366/2022

Eva Marín Serrano, Marta Duque Alcorta,

Abstract
Cystic pancreatic neuroendocrine tumors (cP-NET) are a diagnostic challenge for clinic, since sometimes nor imaging features, cytology, or the study of biological markers in pancreatic cyst fluid (PCF), are able to provide the nature of the lesion, and therefore the definitive diagnostic is often made in the surgical piece. Is not infrequent that the lesions are wrongly defined as benign, in special when the cytology is negative for malignancy and the PCL is not mucinous and has a high glucose and a low CEA. We could incorporate new markers to improve the diagnostic performance of PCF samples, like chromogranin A, as in our case may be the only specific finding to detect a cP-TNE.
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References
Nakashima Y, Ohtsuka T, Nakamura S, et al. Clinicopathological characteristics of non-functioning cystic pancreatic neuroendocrine tumors. Pancreatology. 2019; 19(1): 50-56.
Sakorafas GH, Smyrniotis V, Reid-Lombardo KM, et al. Primary pancreatic cystic neoplasms of the pancreas revisited. Part IV: rare cystic neoplasms. Surg Oncol. 2012; 21(3):153-63.
Morales-Oyarvide V, Yoon WJ, Ingkakul T, et al. Cystic pancreatic neuroendocrine tumors: the value of cytology in preoperative diagnosis. Cancer Cytopathol. 2014; 122(6): 435-44.
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Faias S, Prazeres S, Cunha M, et al. Chromogranin A and NSE in cystic pancreatic neuroendocrine tumors. Clin Res Hepatol Gastroenterol. 2021; 45(4):101601.
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Marín Serrano E, Duque Alcorta M. Diagnosis of a cystic pancreatic neuroendocrine tumor: is cystic fluid chromogranin A useful?. 9366/2022


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Publication history

Received: 16/11/2022

Accepted: 22/11/2022

Online First: 01/12/2022

Published: 06/09/2023

Article Online First time: 15 days

Article editing time: 294 days


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