Year 2016 / Volume 108 / Number 10
Case Report
Glycogenic hepatopathy in young adults: a case series

673-676

DOI: 10.17235/reed.2016.3934/2015

Marco Silva, Margarida Marques, Hélder Cardoso, Susana Rodrigues, Patrícia Andrade, Armando Peixoto, Joana Pardal, Joanne Lopes, Fátima Carneiro, Guilherme Macedo,

Abstract
Glycogenic hepatopathy is a rare and under-recognized complication in long-standing poorly controlled type 1 diabetes mellitus patients. This is a distinct entity from other causes of hepatomegaly and elevated liver enzymes in diabetics, such as nonalcoholic fatty liver disease. Glycogenic hepatopathy is characterized by the combination of poorly controlled diabetes, acute liver injury with marked elevation in serum aminotransferases, and the characteristic histological features on liver biopsy. It is important to distinguish this entity as it has the potential for resolution following improved glycemic control. In this report, we describe four cases of adult patients presenting elevated serum transaminases and hepatomegaly with a history of poorly controlled type I diabetes mellitus. One of the patients had also elevated amylase and lipase in the serum, without clinical or imagiologic evidence of acute pancreatitis (AP). Liver biopsy was performed in all patients and revealed glycogenic hepatopathy. Clinician’s awareness of glycogenic hepatopathy should prevent diagnostic delay or misdiagnosis and will provide better insight and management for this condition.
Share Button
New comment
Comments
No comments for this article
References
1. Hudacko RM, Manoukian AV, Schneider SH et al. Clinical resolution of glycogenic hepatopathy following improved glycemic control. J Diabetes Complications 2008; 22: 329–30.
2. Bassett JT, Veerappan GR, Lee DH. Glycogenic hepatopathy: a rare cause of increased aminotransferase levels in a diabetic patient. Clin Gastroenterol Hepatol 2008; 6: A26.
3. Abaci A, Bekem O, Unuvar T et al. Hepatic glycogenosis: a rare cause of hepatomegaly in Type 1 diabetes mellitus. J Diabetes Complications 2008; 22: 325–8.
4. García-Suárez C, Suárez BA, Ortiz EC et al. Glycogenic hepatopathy: a rare and reversible cause of elevated transaminases in diabetic patients. Case report. Rev Esp Enferm Dig 2015; 107: 111-2.
5. Munns CF, McCrossin RB, Thomsett MJ et al. Hepatic glycogenosis: reversible hepatomegaly in type 1 diabetes. J Paediatr Child Health 2000; 36: 449–52.
6. Cuthbertson DJ, Brennan G, Walsh S et al. Hepatic glycogenosis: abnormal liver function tests in Type 1 diabetes. Diabet Med 2007; 24: 322–3.
7. Imtiaz KE, Healy C, Sharif S et al. Glycogenic hepatopathy in type 1 diabetes: an underrecognized condition. Diabetes Care 2013; 36: e6–7.
8. Yadav D, Nair S, Norkus EP et al. Nonspecific hyperamylasemia and hyperlipasemia in diabetic ketoacidosis: incidence and correlation with biochemical abnormalities. Am J Gastroenterol 2000; 95: 3123–8.
9. Tetrault GA. Lipase activity in serum measured with Ektachem is often increased in nonpancreatic disorders. Clin Chem 1991; 37: 447–51.
10. Julián MT, Alonso N, Ojanguren I et al. Hepatic glycogenosis: An underdiagnosed complication of diabetes mellitus? World J Diabetes 2015; 6: 321–5.
11. Cha JH, Ra SH, Park YM et al. Three cases of glycogenic hepatopathy mimicking acute and relapsing hepatitis in type I diabetes mellitus. Clin Mol Hepatol 2013; 19: 421–5.
12. Torbenson M, Chen Y-Y, Brunt E et al. Glycogenic hepatopathy: an underrecognized hepatic complication of diabetes mellitus. Am J Surg Pathol 2006; 30: 508–13.
13. Saadi T. Glycogenic hepatopathy: a rare disease that can appear and resolve rapidly in parallel with glycemic control. Isr Med Assoc J 2012; 14: 269–70.
Related articles

Letter

An unusual cause of liver lesions

DOI: 10.17235/reed.2023.9787/2023

Editorial

Orthohepevirus C as causal agent of acute hepatitis in Spain

DOI: 10.17235/reed.2022.8993/2022

Letter

A case of COVID-19 with concomitant infection with hepatitis A

DOI: 10.17235/reed.2021.8372/2021

Letter

Unexpected diagnosis for nodular hepatic lesions

DOI: 10.17235/reed.2021.8230/2021

Original

A new pattern in hepatitis A virus infection in an urban population

DOI: 10.17235/reed.2020.6526/2019

Case Report

Using octreotide for refractory ascites after liver transplantation

DOI: 10.17235/reed.2019.6316/2019

Letter

Acute seronegative hepatitis C: two case reports

DOI: 10.17235/reed.2019.5921/2018

Letter to the Editor

Hepatic glycogenosis: a diagnostic challenge

DOI: 10.17235/reed.2017.4605/2016

Citation tools
Silva M, Marques M, Cardoso H, Rodrigues S, Andrade P, Peixoto A, et all. Glycogenic hepatopathy in young adults: a case series. 3934/2015


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 923 visits.
This article has been downloaded 75 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 19/07/2015

Accepted: 16/09/2015

Online First: 22/02/2016

Published: 30/09/2016

Article revision time: 58 days

Article Online First time: 218 days

Article editing time: 439 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology