Year 2021 / Volume 113 / Number 8
Original
Clinical study of a 125I particle-integrated esophageal covered stent and hyperbaric oxygen in the treatment of advanced esophageal cancer

576-579

DOI: 10.17235/reed.2020.7377/2020

Qi-zhou Zhang, Guo-liang Li, Jian-biao Shang, Yi-min Ren, Jian-li Xie,

Abstract
Objective: this study aimed to investigate the clinical efficacy and feasibility of the treatment of advanced esophageal cancer with a combination of a 125I particle-integrated esophageal covered stent and hyperbaric oxygen. Methods: forty-five patients with advanced esophageal cancer were enrolled and were randomly divided into two groups: a treatment group and a control group. Patients in the treatment group were treated with a 125I particle-integrated esophageal covered stent and hyperbaric oxygen, while patients in the control group were treated with a 125I particle-integrated esophageal covered stent. The clinical effects and long-term survival time of the two groups were observed. Results: in the treatment group, the complete remission (CR) rate and partial remission (PR) rate of local lesions were 19.2 % and 61.5 %, respectively, and the total effective rate was 80.7 %. In the control group, the CR rate and PR rate of local lesions were 10.5 % and 52.6 %, respectively, and the total effective rate was 63.1 %. The total effective rate was higher in the treatment group than in the control group, which was statistically significant (p < 0.05). Conclusion: the combination of a 125I particle-integrated esophageal covered stent and hyperbaric oxygen shows a good short- and long-term efficacy in the treatment of advanced esophageal cancer.
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References
[1]Nakajima M, Muroi H, Kikuchi M, Takahashi M, Ihara K, Shida Y, Kurayama E, Ogata H, Yamaguchi S, Sasaki K, Sakai M, Sohda M, Miyazaki T, Kuwano H, Kato H. Adverse Prognostic Factors of Advanced Esophageal Cancer in Patients Undergoing Induction Therapy with Docetaxel, Cisplatin and 5-Fluorouracil. anticancer research, 2018, 38(2):911-918.
[2]Anghel R, Constantinoiu S, Bacinschi X, Gales L, Toma RV, Trifanescu O. Distant Oncologic Outcome of Patients with Locally Advanced Unresectable and Metastatic Esophageal Cancer after Multimodality Treatment. Chirurgia, 2018, 113(1):116.
[3]Deng W , Lin S H . Advances in radiotherapy for esophageal cancer. annals of translational medicine, 2018, 6(4):79.
[4]Park I H , Kim J Y . Surveillance or resection after chemoradiation in esophageal cancer[J]. ann transl med, 2018, 6(4):82.
[5]Tu C C , Hsu P K . The frontline of esophageal cancer treatment: questions to be asked and answered. Ann Transl Med, 2018, 6(4):83-83.
[6]Guo JC, Lin CC, Huang TC, Huang PM, Kuo HY, Chang CH, Wang CC, Cheng JC, Yeh KH, Hsu CH, Lee JM. Number of Resected Lymph Nodes and Survival of Patients with Locally Advanced Esophageal Squamous Cell Carcinoma Receiving Preoperative Chemoradiotherapy. Anticancer Research, 2018, 38(3):1569-1577.
[7]Singla S, Gabriel E, Alnaji R, Du W, Attwood K, Nava H, Hochwald SN, Kukar M. Complete pathologic response is independent of the timing of esophagectomy following neoadjuvant chemoradiation for esophageal cancer. Journal of Gastrointestinal Oncology, 2018, 9(1):73-79.
[8]Guo JH, Teng GJ, Zhu GY, He SC, Fang W, Deng G, Li GZ. Self-expandable esophageal stent loaded with 125I seeds: initial experience in patients with advanced esophageal cancer. Radiology, 2008, 247(2):574-81.
[9]Wang F A , Xu F L , Guo J H . Clinical application of esophageal stent loaded with 125I seeds: Recent progress in research. Journal of Interventional Radiology, 2009, 18(9):713-716.
[10]Zhang S , Lv B . Self-expandable medical memorial metallic stent with 125I seeds for the treatment of esophageal carcinoma: A retrospective analysis. journal of interventional radiology, 2011, 20(6):444-447.
[11]Yin J , Chen J D . Intestinal electrical stimulation and the promotion of fat excretion: a potential treatment for obesity? Clinical Lipidology, 2009, 4(6):691-693.
[12]Tian D , Wen H , Fu M . Comparative study of self-expanding metal stent and intraluminal radioactive stent for inoperable esophageal squamous cell carcinoma. World Journal of Surgical Oncology, 2015, 14(1):18.
[13]Zhao P, Zhang MQ, Zhang YL, Guo YC, Zhao YL, Wu QW, Zhao YA, Zhang XZ. Application of esophageal irradiation stents coated with 125I particles in advanced esophageal cancer. Journal of B.u.on. Official Journal of the Balkan Union of Oncology, 2017, 22(1):265.
[14]Fletcher GH, Lindberg RD, Caderao JB, Wharton JT. Hyperbaric oxygen as a radiotherapeutic adjuvant in advanced cancer of the uterine cervix. Preliminary results of a radomized trial. Cancer, 2015, 39(2):617-623.
[15]Kajiya Y , Uchiyama N , Nakajo M . Hyperbaric Oxygen Therapy for Reducing Adverse Events of Chemoradiation therapy for Esophageal Cancer. International Journal of Radiation Oncology*Biology*Physics, 2012, 84(3):S304.
[16]Stroh EL, Besa PC, Cox JD, Fuller LM, Cabanillas FF. Treatment of patients with lymphomas of the uterus or cervix with combination chemotherapy and radiation therapy. Cancer (Philadelphia), 1995, 75(9):2392-2399.
[17]Maier A, Tomaselli F, Anegg U, Rehak P, Fell B, Luznik S, Pinter H, Smolle-Jüttner FM. Combined photodynamic therapy and hyperbaric oxygenation in carcinoma of the esophagus and the esophago-gastric junction. European Journal of Cardio-Thoracic Surgery, 2000, 18(6):649-655.
[18]Maier A, Anegg U, Fell B, Rehak P, Ratzenhofer B, Tomaselli F, Sankin O, Pinter H, Smolle-Jüttner FM, Friehs GB. Hyperbaric oxygen and photodynamic therapy in the treatment of advanced carcinoma of cardia and esophagus. Lasers in Surgery & Medicine, 2000, 26(3):308-315.
[19]Huang L , Boling W , Zhang J . Hyperbaric oxygen therapy as adjunctive strategy in treatment of glioblastoma multiforme. medical gas research, 2018, 8(1):24-28.
[20]Wang H, Gao Z, Liu X, Agarwal P, Zhao S, Conroy DW, Ji G, Yu J, Jaroniec CP, Liu Z, Lu X, Li X, He X. Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance. Nature Communications, 2018, 9(1):562.
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Zhang Q, Li G, Shang J, Ren Y, Xie J. Clinical study of a 125I particle-integrated esophageal covered stent and hyperbaric oxygen in the treatment of advanced esophageal cancer. 7377/2020


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Publication history

Received: 28/06/2020

Accepted: 21/09/2020

Online First: 02/12/2020

Published: 28/07/2021

Article revision time: 77 days

Article Online First time: 157 days

Article editing time: 395 days


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