Year 2024 / Volume 116 / Number 4
Letter
The significance of appendectomy in the context of colorectal cancer: impacts on gut microbiota and beyond

224-225

DOI: 10.17235/reed.2023.9657/2023

Yunzhen Lin, Tianhang Li,

Abstract
Colorectal cancer (CRC) remains one of the most common malignancies globally, of which the initiative factors are multiple and complex. More recently, the major roles played by gut microbiota in the carcinogenesis of CRC have been uncovered, which indicates that dysbiosis caused by specific bacterial or fungal species may contribute to the malignant progression of CRC. Meanwhile, appendix, classically identified as an evolutionary relict with negligible physiological functions, has been found to play crucial roles in the immune modulation process and microbiome composition of gut by its lymphoid tissue features. In addition, appendectomy, a common surgical operation modality, has also been found to be closely correlated with the clinical outcomes of multiple diseases, including CRC. Naturally, these evidence collectively point to a possibility that the appendectomy may influence the pathological process of CRC through its impacts on gut microbiome.
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References
1. Shi F, Liu G, Lin Y, et al. Altered gut microbiome composition by appendectomy contributes to colorectal cancer. Oncogene. 2023;42(7):530-540. doi:10.1038/s41388-022-02569-3
2. Bender MJ, McPherson AC, Phelps CM, et al. Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment [published online ahead of print, 2023 Apr 4]. Cell. 2023;S0092-8674(23)00271-4. doi:10.1016/j.cell.2023.03.011
3. Lu Y, Yuan X, Wang M, et al. Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies. J Hematol Oncol. 2022;15(1):47. Published 2022 Apr 29. doi:10.1186/s13045-022-01273-9
4. Wang T, Fan C, Yao A, et al. The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells. Immunity. 2018;49(3):504-514.e4. doi:10.1016/j.immuni.2018.08.018
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Lin Y, Li T. The significance of appendectomy in the context of colorectal cancer: impacts on gut microbiota and beyond. 9657/2023


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Publication history

Received: 11/04/2023

Accepted: 17/04/2023

Online First: 28/04/2023

Published: 09/04/2024

Article Online First time: 17 days

Article editing time: 364 days


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