Year 2022 / Volume 114 / Number 2
Letter
EBVMCU in a liver-transplant patient

121-122

DOI: 10.17235/reed.2021.8064/2021

Marta Librero Jiménez, María Dolores Espinosa Aguilar,

Abstract
A 36-year-old male was admitted to our hospital with diarrhea, weakness and loss of appetite over two months. He had received a liver transplant two years before and was taking immunosuppressors (everolimus, mycophenolate mofetil and tacrolimus). Initial laboratory tests showed iron-deficiency anemia (Hb 9.8 g/dl), lymphopenia and mild elevation in C-reactive protein (35 mg/l). Blood and stool cultures, and cytomegalovirus (CMV) quantitation in blood were all negative. Finally, the colonoscopy showed two rectal fimbriated ulcers close to the anal sphincter and multiple biopsies from the ulcer margins identified the presence of Epstein-Barr virus (EBV). All symptoms were completely resolved three weeks after immunosuppression was diminished. He underwent a follow-up colonoscopy, without any evidence of the former ulcers.
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References
(1): SATOU A, KOHNO A, FUKUYAMA R, ET AL. Epstein-Barr virus–positive mucocutaneous ulcer arising in a post–hematopoietic cell transplant patient followed by polymorphic posttransplant lymphoproliferative disorder and cytomegalovirus colitis. Hum Pathol. 2017 Jan; 59: 147-51.
(2): HART M, THAKRAL B, YOHE S, ET AL. EBV-positive Mucocutaneous Ulcer in Organ Transplant Recipients: a localized indolent posttransplant lymphoproliferative disorder. Am J Surg Pathol. 2014 Nov; 38 (11): 1522-9.
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Librero Jiménez M, Espinosa Aguilar M. EBVMCU in a liver-transplant patient. 8064/2021


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Publication history

Received: 25/04/2021

Accepted: 03/09/2021

Online First: 14/09/2021

Published: 07/02/2022

Article revision time: 118 days

Article Online First time: 142 days

Article editing time: 288 days


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