Year 2017 / Volume 109 / Number 5
Case Report
Intrahepatic clear cell cholangiocarcinoma - An uncommon histologic subtype: case report and literature review

382-385

DOI: 10.17235/reed.2017.4239/2016

Samuel Raimundo Fernandes, Cilénia Baldaia, Hugo Pinto Marques, Francisco Tortosa, Fernando Ramalho,

Abstract
Clear-cell cholangiocarcinoma is a very uncommon variant of cholangiocarcinoma with a largely unknown natural history and prognosis. We report a case of a 51-year-old previously healthy woman presenting with a large liver nodule found on routine imaging. Needle biopsy of the lesion suggested a non-hepatocellular carcinoma. After extensive workup for other primary neoplasms, the patient underwent a partial hepatectomy. Histopathology was compatible with a moderately differentiated clear-cell cholangiocarcinoma. There was no evidence of liver disease in the remaining tissue. The patient underwent chemotherapy and remains in clinical remission after two years.
Share Button
New comment
Comments
No comments for this article
References
1. Everhart J, Ruhl C. Burden of Digestive Diseases in the United States Part III: Liver, Biliary Tract, and Pancreas. Gastroenterology. 2009;136(4):1134-1144.
2. Toriyama E. A case of intrahepatic clear cell cholangiocarcinoma. World Journal of Gastroenterology. 2010;16(20):2571.
3. Haas S, Gütgemann I, Wolff M, Fischer H. Intrahepatic Clear Cell Cholangiocarcinoma. The American Journal of Surgical Pathology. 2007;31(6):902-906.
4. Tihan T, Blumgart L, Klimstra D. Clear cell papillary carcinoma of the liver: An unusual variant of peripheral cholangiocarcinoma. Human Pathology. 1998;29(2):196-200.
5. Falta EM, Rubin AD, Harris JA. Peripheral clear cell cholangiocarcinoma: A rare histologic variant. Am Surg. 1999;65(6):592–5.
6. Logani S, Adsay V. Clear cell cholangiocarcinoma of the liver is a morphologically distinctive entity. Human Pathology. 1998;29(12):1548-1549.
7. Adamek H, Spiethoff A, Kaufmann V, Jakobs R, Riemann J. Primary clear cell carcinoma of noncirrhotic liver: immunohistochemical discrimination of hepatocellular and cholangiocellular origin. Digestive Diseases and Sciences. 1998;43(1):33-38.
8. Albores-Saavedra J, Hoang M, Murakata L, Sinkre P, Yaziji H. Atypical Bile Duct Adenoma, Clear Cell Type. The American Journal of Surgical Pathology. 2001;25(7):956-960.
9. Wee A. Diagnostic Utility of Immunohistochemistry in Hepatocellular Carcinoma, its Variants and Their Mimics. Applied Immunohistochemistry & Molecular Morphology. 2006;14(3):266-272.
10. Mavros M, Economopoulos K, Alexiou V, Pawlik T. Treatment and Prognosis for Patients With Intrahepatic Cholangiocarcinoma. JAMA Surgery. 2014;149(6):565.
Related articles
Citation tools
Fernandes S, Baldaia C, Pinto Marques H, Tortosa F, Ramalho F. Intrahepatic clear cell cholangiocarcinoma - An uncommon histologic subtype: case report and literature review. 4239/2016


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 955 visits.
This article has been downloaded 238 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 30/01/2016

Accepted: 01/10/2016

Online First: 03/02/2017

Published: 03/05/2017

Article revision time: 241 days

Article Online First time: 370 days

Article editing time: 459 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology