Year 2020 / Volume 112 / Number 1
Review
Vedolizumab for treatment of chronic refractory pouchitis: a systematic review with pool analysis

59-63

DOI: 10.17235/reed.2019.6336/2019

Davide Giuseppe Ribaldone, Rinaldo Pellicano, Giorgio Maria Saracco, Mario Morino, Marco Astegiano,

Abstract
Background and objectives: about 1%-2% of patients with chronic refractory pouchitis, in the context of ulcerative colitis, end up with a permanent ileostomy. The aim of this systematic review was to collect all published studies involving patients treated with vedolizumab for chronic refractory or antibiotic-dependent pouchitis and then pool the data regarding the effectiveness of this therapeutic strategy. Methods: a MEDLINE and Web of Science search of all studies published in English until March 17, 2019 was conducted using the terms “vedolizumab and pouchitis”. Results: seven studies with a total of 44 patients with chronic pouchitis were included. Twenty-three out of 44 patients (52.3%) had undergone previous treatment with anti-tumor necrosis factor (TNF) drugs. At week 12, 33 out of 44 patients (75%) reported clinical improvement. Endoscopic improvement, evaluated within 6 months of the start of vedolizumab therapy, was obtained in 28 out of the 38 patients in whom such data were available (73.7%). Conclusions: this first systematic review published in the literature on this issue suggests that vedolizumab has significant efficacy in chronic refractory or antibiotic-dependent pouchitis, also in patients who failed to respond to other treatments including those with anti-TNF agents.
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References
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Ribaldone D, Pellicano R, Saracco G, Morino M, Astegiano M. Vedolizumab for treatment of chronic refractory pouchitis: a systematic review with pool analysis. 6336/2019


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Publication history

Received: 12/04/2019

Accepted: 11/11/2019

Online First: 11/12/2019

Published: 10/01/2020

Article revision time: 209 days

Article Online First time: 243 days

Article editing time: 273 days


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