Year 2016 / Volume 108 / Number 7
Original
Spanish multicenter study to estimate the incidence of chronic pancreatitis

411-416

DOI: 10.17235/reed.2016.4056/2015

J. Enrique Domínguez Muñoz, Alfredo José Lucendo Villarín, L. Fernando Carballo Álvarez, Jose María Tenías, Julio Iglesias García,

Abstract
Objective: To estimate the incidence of chronic pancreatitis in Spain as diagnosed with endoscopic ultrasound (EUS), and to assess the risk factors and complications detected. Material and method: A descriptive, observational study of chronic pancreatitis cases diagnosed in Spanish health care centers with an EUS unit. A structured questionnaire was used to evaluate the incidence of the disease (cases identified over 18 months: from January 2011 to June 2012), risk factors, EUS criteria, Rosemont classification, and frequency of local complications. Results: Twenty-three centers were selected serving a total reference area of 14,752,704 population. During the study period 1,031 chronic pancreatitis cases were diagnosed, with an incidence of 4.66 cases per 105 inhabitants/year (95% CI: 4.65-4.67). Tobacco and alcohol use appear as risk factors in 63.8% and 66.7% of cases, respectively. Of these, 53.3% met > 5 EUS criteria for chronic pancreatitis, and 69% had findings suggestive of or consistent with chronic pancreatitis according to the Rosemont classification. Most prevalent complications included calcifications (34.7%), pseudocysts (16%), and presence of an inflammatory pancreatic tumor (10.4%). Conclusions: The incidence of chronic pancreatitis in Spain is similar to that of other European countries. Given the widespread use of the technique, EUS units are key in detecting the disease, and their activity and results allow to estimate the incidence of chronic pancreatitis over wide, representative population areas.
Share Button
New comment
Comments
No comments for this article
References
REFERENCIAS
1. Jupp J, Fine D, Johnson CD. The epidemiology and socioeconomic impact of chronic pancreatitis. Best Pract Res Clin Gastroenterol 2010; 24(3): 219-31.
2. Johnson CD, Hosking S. National statistics for diet, alcohol consumption, and chronic pancreatitis in England and Wales, 1960-88. Gut 1991; 32(11): 1401-5.
3. Jaakkola M, Nordback I. Pancreatitis in Finland between 1970 and 1989. Gut 1993; 34(9): 1255-60.
4. Dite P, Stary K, Novotny I, Precechtelova M, Dolina J, Lata J, et al. Incidence of chronic pancreatitis in the Czech Republic. Eur J Gastroenterol Hepatol 2001; 13(6): 749-50.
5. Tinto A, Lloyd DA, Kang JY, Majeed A, Ellis C, Williamson RC, et al. Acute and chronic pancreatitis--diseases on the rise: a study of hospital admissions in England 1989/90-1999/2000. Aliment Pharmacol Ther 2002; 16(12): 2097-105.
6. Ryu JK, Lee JK, Kim YT, Lee DK, Seo DW, Lee KT, et al. Clinical features of chronic pancreatitis in Korea: a multicenter nationwide study. Digestion 2005; 72(4): 207-11.
7. Levy P, Barthet M, Mollard BR, Amouretti M, Marion-Audibert AM, Dyard F. Estimation of the prevalence and incidence of chronic pancreatitis and its complications. Gastroenterol Clin Biol 2006; 30(6-7): 838-44.
8. Otsuki M, Tashiro M. 4. Chronic pancreatitis and pancreatic cancer, lifestyle-related diseases. Intern Med 2007; 46(2): 109-13.
9. Nishimori I, Tamakoshi A, Otsuki M. Prevalence of autoimmune pancreatitis in Japan from a nationwide survey in 2002. J Gastroenterol 2007; 42 Suppl 18: 6-8.
10. Yang AL, Vadhavkar S, Singh G, Omary MB. Epidemiology of alcohol-related liver and pancreatic disease in the United States. Arch Intern Med 2008; 168(6): 649-56.
11. Spanier BW, Dijkgraaf MG, Bruno MJ. Trends and forecasts of hospital admissions for acute and chronic pancreatitis in the Netherlands. Eur J Gastroenterol Hepatol 2008; 20(7): 653-8.
12. Balakrishnan V, Unnikrishnan AG, Thomas V, Choudhuri G, Veeraraju P, Singh SP, et al. Chronic pancreatitis. A prospective nationwide study of 1,086 subjects from India. JOP 2008; 9(5): 593-600.
13. Frulloni L, Gabbrielli A, Pezzilli R, Zerbi A, Cavestro GM, Marotta F, et al. Chronic pancreatitis: report from a multicenter Italian survey (PanCroInfAISP) on 893 patients. Dig Liver Dis 2009; 41(4): 311-7.
14. Wang LW, Li ZS, Li SD, Jin ZD, Zou DW, Chen F. Prevalence and clinical features of chronic pancreatitis in China: a retrospective multicenter analysis over 10 years. Pancreas 2009; 38(3): 248-54.
15. Joergensen M, Brusgaard K, Cruger DG, Gerdes AM, de Muckadell OB. Incidence, prevalence, etiology, and prognosis of first-time chronic pancreatitis in young patients: a nationwide cohort study. Dig Dis Sci 2010; 55(10): 2988-98.
16. Dzieniszewski J, Jarosz M, Ciok J. Chronic pancreatitis in Warsaw. Mater Med Pol. 1990; 22(3): 202-4.
17. Domínguez Muñoz E, Lucendo A, Carballo LF, Iglesias-Garcia J, Tenías JM, et al. A Spanish multicenter study to estimate the prevalence and incidence of chronic pancreatitis and its complications. Rev Esp Enf Digest. 2014; 106 (4): 239-45.
18. Choueiri NE, Balci NC, Alkaade S, Burton FR. Advanced imaging of chronic pancreatitis. Curr Gastroenterol Rep 2010; 12: 114-20
19. Wiersema MJ, Hawes RH, Lehman GA, Kochman ML, Sherman S, Kopecky KK. Prospective evaluation of endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography in patients with chronic abdominal pain of suspected pancreatic origin. Endoscopy 1993; 25 (9): 555-64
20. Catalano MF, Sahai A, Levy M, Romagnuolo J, Wiersema M, Brugge W, et al. EUS-based criteria for the diagnosis of chronic pancreatitis: the Rosemont classification. Gastrointest Endosc. 2009; 69(7): 1251-61.
21. Iglesias-Garcia J, Lariño-Noia J, Lindkvist B, Dominguez-Muñoz JE. Endoscopic Ultrasound in the diagnosis of chronic pancreatitis. Rev Esp Enf Dig. 2015; 107; 221-8.
22. Kahl S, Glasbrenner B, Leodolter A, Pross M, Schulz HU, Malfertheiner P. EUS in the diagnosis of early chronic pancreatitis: a prospective follow-up study. Gastrointest Endosc 2002; 55(4): 507-11.
23. Masson E, Chen JM, Audrezet MP, Cooper DN, Ferec C. A conservative assessment of the major genetic causes of idiopathic chronic pancreatitis: Data from a comprehensive analysis of PRSS1, SPINK1, CTRC and CFTR genes in 253 young French patients. PloS one 2013;8:e73522.
24. Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology 2013;144:1252-61.
25. Spicak J, Pulkertova A, Kralova-Lesna I, Suchanek P, Vitaskova M, Adamkova V. Alcoholic chronic pancreatitis and liver cirrhosis: Coincidence and differences in lifestyle. Pancreatology 2012;12:311-6.
26. Lowenfels AB, Maisonneuve P. Defining the role of smoking in chronic pancreatitis. Clin Gastroenterol Hepatol 2011;9:196-7.
27. Bhutani MS, Arantes VN, Verma D, Moezzi J, Suryaprasad S, Kapadia AS, et al. Histopathologic correlation of endoscopic ultrasound findings of chronic pancreatitis in human autopsies. Pancreas 2009; 38(7): 820-4.
28. Varadarajulu S, Eltoum I, Tamhane A, Eloubeidi MA. Histopathologic correlates of noncalcific chronic pancreatitis by EUS: a prospective tissue characterization study. Gastrointest Endosc 2007; 66(3): 501-9.
29. LeBlanc JK, Chen JH, Al-Haddad M, Juan M, Okumu W, McHenry L, et al. Endoscopic ultrasound and histology in chronic pancreatitis: how are they associated? Pancreas 2014; 43(3): 440-4.
Related articles

Letter

Duodenal lymphangiomas: endoscopic ultrasound features

DOI: 10.17235/reed.2024.10338/2024

Letter

Spontaneous cystogastric fistula: an accidental discovery

DOI: 10.17235/reed.2023.9912/2023

Digestive Diseases Image

Imaging of pancreatic desmoid fibromatosis by endoscopic ultrasound

DOI: 10.17235/reed.2023.9792/2023

Digestive Diseases Image

Endosonographic and ERCP findings in COVID-19 critical illness cholangiopathy

DOI: 10.17235/reed.2022.9218/2022

Letter

Angiosarcoma of the aorta diagnosed via endoscopic ultrasound

DOI: 10.17235/reed.2022.8879/2022

Digestive Diseases Image

Pancreatic lymphoma during pregnancy

DOI: 10.17235/reed.2022.8811/2022

Digestive Diseases Image

When needles are not enough, forceps delivers!

DOI: 10.17235/reed.2022.8697/2022

Original

Radon exposure and inflammatory bowel disease in a radon prone area

DOI: 10.17235/reed.2021.8239/2021

Letter

Lumen-apposing metal stent deployment failure

DOI: 10.17235/reed.2020.7060/2020

Letter

Sometimes things are what they seem

DOI: 10.17235/reed.2019.5911/2018

Letter

A giant abdominal collection: when things are not what they seem

DOI: 10.17235/reed.2018.5642/2018

Letter to the Editor

Late migration of a metal stent after EUS-drainage of a pancreatic pseudocyst abscess

DOI: 10.17235/reed.2018.5411/2017

Letter to the Editor

EUS-guided ethanol ablation therapy for gastric stromal tumors

DOI: 10.17235/reed.2017.5361/2017

Letter to the Editor

A rectal neuroendocrine neoplasm

DOI: 10.17235/reed.2017.4836/2017

Letter to the Editor

Genetics in idiopathic pancreatitis and acute recurrent pancreatitis

DOI: 10.17235/reed.2017.4632/2016

Review

Endoscopic ampullectomy: a technical review

DOI: 10.17235/reed.2016.3867/2015

Case Report

Pseudoaneurysm associated with complicated pancreatic pseudocysts

DOI: 10.17235/reed.2016.3855/2015

Case Report

Pelvic inflammatory myofibroblastic tumor mimicking a rectal cancer

DOI: 10.17235/reed.2015.3777/2015

Citation tools
Domínguez Muñoz J, Lucendo Villarín A, Carballo Álvarez L, Tenías J, Iglesias García J. Spanish multicenter study to estimate the incidence of chronic pancreatitis . 4056/2015


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1150 visits.
This article has been downloaded 194 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 17/10/2015

Accepted: 18/03/2016

Online First: 17/06/2016

Published: 11/07/2016

Article revision time: 150 days

Article Online First time: 244 days

Article editing time: 268 days


Share
This article has been rated by 2 readers.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology