Year 2020 / Volume 112 / Number 10
Original
Autoimmune sequential overlap syndrome (autoimmune hepatitis/primary sclerosing cholangitis) and inflammatory bowel disease: three clinical cases

788-791

DOI: 10.17235/reed.2020.6938/2020

Paulina Núñez Figueroa, Rocío Sedano Muñoz, Rodrigo Quera Pino, Gonzalo Carrasco-Avino, Andrés O´Brien, Javier Brahm Barril,

Abstract
Inflammatory bowel disease (IBD) is related to different liver extraintestinal manifestations and occurs with or without a link to disease activity. Primary sclerosing cholangitis (PSC) is the most common hepatobiliary manifestation. Other autoimmune hepatopathies may develop during the evolution of the latter, which is known as overlap syndrome. Sequential overlap syndrome occurs when these conditions appear in subsequent stages, and it is less frequently associated with IBD. We report three cases of sequential overlap syndrome with autoimmune hepatitis as the first manifestation, followed by PSC after 7-19 years and subsequently IBD. Liver extraintestinal manifestations may precede IBD by several years. Therefore, it is crucial to keep this association in mind, thereby reducing the diagnostic delay.
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Núñez Figueroa P, Sedano Muñoz R, Quera Pino R, Carrasco-Avino G, O´Brien A, Brahm Barril J, et all. Autoimmune sequential overlap syndrome (autoimmune hepatitis/primary sclerosing cholangitis) and inflammatory bowel disease: three clinical cases . 6938/2020


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Publication history

Received: 04/02/2020

Accepted: 14/03/2020

Online First: 21/09/2020

Published: 07/10/2020

Article revision time: 33 days

Article Online First time: 230 days

Article editing time: 246 days


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