Year 2020 / Volume 112 / Number 9
Letter
Effective treatment of autoimmune hepatitis-primary biliary cholangitis overlap syndrome with obeticholic acid

737

DOI: 10.17235/reed.2020.6883/2020

Juan Diego Castro Limo, Marta Romero-Gutiérrez, Juan Ruiz Martín,

Abstract
There is no consensus treatment for patients with autoimmune hepatitis (AIH) – primary biliary cholangitis (PBC) overlap syndrome who are not responding to conventional therapy. We present a case of a 43-yr-old woman with AIH-PBC overlap syndrome treated with obeticholic acid (OCA). The patient showed a reduction in liver enzymes and no fibrosis progression during 15 months of follow up.
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03/05/2021 20:50:35
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References
1. Zhang W, De D, Mohammed K, Munigala S, et al. New scoring classification for primary biliary cholangitis-autoinmmune hepatitis overlap syndrome. Hepatology Communications 2018; 2(3): 245-253.
2. European Association for the Study of the Liver. EASL clinical practice guidelines: the diagnosis and management of patients with primary biliary cholangitis. J Hepatol 2017;67(1):145-172.
3. Martínez J, Aguilera L, Albillos A. Risk stratification and treatment of primary biliary cholangitis. Rev Esp Enferm Dig. 2019 Jan;111(1):63-70.
4. Nevens F, Andreone P, Mazzella G, et al. A placebo-controlled trial of obeticholic acid in primary biliary cholangitis. N Engl J Med 2016; 375:631-643.
5. Corpechot C, Carrat F, Poujol-Robert A, et al. Noninvasive elastography-based assessment of liver fibrosis progression and prognosis in primary biliary cirrhosis. Hepatology 2012;56(1):198-208.
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Castro Limo J, Romero-Gutiérrez M, Ruiz Martín J. Effective treatment of autoimmune hepatitis-primary biliary cholangitis overlap syndrome with obeticholic acid. 6883/2020


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Publication history

Received: 15/01/2020

Accepted: 21/01/2020

Online First: 04/06/2020

Published: 10/09/2020

Article Online First time: 141 days

Article editing time: 239 days


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