Year 2021 / Volume 113 / Number 1
Review
Inflammatory bowel disease and solid organ transplantation

60-64

DOI: 10.17235/reed.2020.7361/2020

María del Pilar Martínez Montiel, Begoña Casis Herce,

Abstract
The population of patients with inflammatory bowel disease (IBD) and solid organ transplant (SOT) is increasing. Two clinical scenarios exist, recurrence of pre-existing IBD, which is more common, and de novo development of IBD, with a much higher incidence than in the general population. Their clinical course differs and may have a negative impact on the graft in both cases. The pathophysiological mechanisms remain unknown and no specific treatment recommendations are available. The combined effect of biologic therapy against IBD and immunosuppressive therapy against a potential rejection means that close monitoring is mandatory to identify infection, autoimmune events and malignancies. The colorectal cancer (CRC) rate is higher in this population. The group at greatest risk are patients with IBD undergoing liver transplantation (LT) for primary sclerosing cholangitis (PSC).
Share Button
New comment
Comments

18/04/2023 0:01:16
RECOVERY OF LOST FUNDS FROM SCAMMER.

Tracking Down Lost Bitcoins and Other Cryptos: Fast without wasting time Contact: Telegram: https://t.me/WizardWebRecovery / Email: wizardwebrecovery@gmail.com, Do you need support of recovery of your lost or stolen bitcoin, trying to obtain cryptocurrency transferred to the wrong wallet address, or believe your wallet has been compromised, get in touch with Wizard Web Recovery Group Hackers . I lost over 412,040 $ after participating in a SINCODE binary scam. The money I fraudulently lost has been recovered thanks to the super work of Wizard Web Recovery Group Hackers . They Working with the new digital software that recovers funds without a twinkle of eyes beep Wizard Web Recovery Group Hackers is trustworthy you can always contact them via
Telegram: https://t.me/WizardWebRecovery
Email: wizardwebrecovery@gmail.com


References
1. Nannegari V, Roque S, Rubin DT et al. A review of inflammatory bowel disease in the setting of liver transplantation. Gastroenterology and Hepatology 2014; 10: 626-630 [PMID: 27540334]
2. Kanizaj TF, Mijic M. Inflammatory bowel disease after liver transplanted patients. World J Gastroenterol 2017; 18: 3214-3227 [PMID: 28566881 DOI:10.3748/wjg.v23.i18.3214]
3. Singh S, Loftus EV, Talwalkar JA. Inflammatory bowel disease after liver transplantation for primary sclerosing cholangitis. Am J Gastroenterol 2013; 108:1417-1425 [PMID: 23896954 DOI: 10.1038/ajg.2013.163. Epub 2013 Jul 30]
4. Joshi D, Bjarnason I, Belgaumkar A, et al. The impact of inflammatory bowel disease post-liver transplantation for primary sclerosing cholangitis. Liver Int 2013; 33: 53-61 [PMID: 22103794 DOI: 10.111/j.1478-3231.2011.02677]
5. Verdonk RC, Dijkstra G, Haagsma EB, et al. Inflammatory bowel disease after liver transplantation: risk factors for recurrence and de novo disease. Am J Transplant 2006; 6: 1422-1429 [PMID: 16686766 DOI: 10.1111/j.1600-6143.2006. 01333.x]
6. Indriolo A, Ravelli P. Clinical management of inflammatory bowel disease in the organ recipient. World J Gastroenterol 2014; 20:3525-3533. [PMID: 24707135 DOI: 10.3748/wjg.v20.i13.3525
7. Hampton DD, Polenski M and Onken J. Inflammatory bowel disease following solid organ transplantation. Clinical Immunolgy 2008;128:287-293. [PMID: 18708022 DOI:10.1016/j.clim.2008.06.011]
8. Jørgensen KK, Lindström L, Cvancarova M, et al. Immunosuppression after liver transplantation for primary sclerosing cholangitis influences activity of inflammatory bowel disease. Clin Gastroenterol Hepatol 2013; 11:517-523 [PMID: 23333218 DOI: 10.1016/j.cgh.2012.12.027]
9. Mouchli MA, Singh S, Boardman L, et al. Natural History of Established and De Novo Inflammatory Bowel Disease After Liver Transplantation for Primary Sclerosing Cholangitis. Inflamm Bowel Dis 2018; 24: 1074-1080 [PMID 29522202
DOI: 10.1093/ibd/izx096.
10.Navaneethan U, Choudhary M, Venkatesh PG, et al. The effects of liver transplantation on the clinical course of colitis in ulcerative colitis patients with primary sclerosing cholangitis. Aliment Pharmacol Ter 2012;35:1054-1063 [PMID: 22428731 DOI: 10.1111/j.1365-2036.2012.05067. x]
11. Mogl M, Baumgart DC, Fisher A, et al. Immunosuppression following liver Transplantation and the course of inflammatory bowel disease-a case control study.
Z Gastroenterol 2018; 56: 117-127 [PMID:29212098 DOI: 10.1055/s-0043-117183.
624]
12.Riley TR, Schoen RE, Lee RG, et al. A case series of transplant recipients who despite immunosuppression developed inflammatory bowel disease. Am J Gastroenterol 1997; 92: 279-282 [PMID: 9040206]
13. Kochlar G, Singh T, Dust H, et al. Impact of the novo and pre-existing inflammatory bowel disease on the outcome of orthotopic liver transplantation. Inflamm Bowel Dis 2016; 22: 1670-1678 [PMID: 27306073 DOI:10.1097/MIB.0000000000000830]
14. Bhat M, Pasini E, Copeland J, et al. Impact of immunosuppression on the metagenomic composition
of the intestinal microbiome: a systems biology Approach to pos-transplant Diabetes. Sci Rep 2017; 31:1-12 [PMID: 28860611 DOI: 10.1038/s41598-017-10471-2]
15. Lv YL, Han FF, Jia YJ, et al. Is cytomegalovirus infection related to inflammatory bowel disease, especially steroid-resistant inflammatory bowel disease? A meta-analysis. Infection and drug resistance 2017;10: 511-519 [PMID: 29276397 DOI: 10.2147/IDR.S149784]
16. Angarone M, Snydman DR. Diagnosis and management of diarrhea in solid-organ transplant recipinets: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clinical Transplantation 2019; 33: 1-10
DOI: 10.1111/ctr.13550
17. Pittman ME, Jessurun J, Yantiss RK. Differentiating posttransplant inflammatory bowel disease and other colitides in renal transplant patients. Am J Surg Pathol. 2017; 41:1666-1674.[PMID:28786879.DOI: 10.1097/PAS.0000000000000921]
18. Ecehenique IA, Penugonda S, Sotosor V, et al. Diagnostic yields in solid organ transplant admitted with diarrhea. Clin Infect Dis 2015; 60: 729-737 [PMID: 25371488 DOI: 10.1093/cid/ciu880 ]
19. EL-Nachef N, Terdiman J, Mahadevan U. Anti-tumour necrosis factor therapy for inflammatory bowel disease in the setting of immunosupression for solid organ transplantation. Am J Gastroenterol 2010; 105:1210-1211 [PMID: 20445523] DOI: 10.1038/ajg],
20. Schnitzler F, Friedrich M, Stallhofer J, et al. Solid Organ Transplantation in Patients with Inflammatory Bowel Diseases (IBD): Analysis of Transplantation Outcome and IBD Activity in a Large Single Center Cohort. PLoS One 2015; 10: e0135807 [PMID: 26288187 DOI: 10.1371/journal.pone.0135807]
21. Altwegg R, Combes R, Laharie D, et al. Effectiveness and safety of anti-TNF therapy for inflammatory bowel disease in liver transplant recipients for primary sclerosing cholangitis: A nationwide case series. Digestive and Liver Disease 2018; 668-674 DOI: 10.1016/j.dld.2018.02.014
22. Westerouen van Meeteren MJ, Hayee B, Inderson A, et al. Safety of Anti-TNF Treatment in Liver Transplant Recipients: A Systematic Review and Meta analysis. J Crohns Colitis. 2017; 11: 1146-1151. [PMID: 28482085 DOI: 10.1093/ecco-jcc/jjx057. Review]
23. Shaikh S, Fitzgerald L, Tischer S. Safety and efficacy of biologic agents for the management of inflammatory bowel disease after liver transplantation. Pharmacotherapy 2017; 37: 1578-1585 [PMID: 27306073 DOI: 10.1002/phar.2036]
24.- M.Martínez-Montiel, Pilar Piedracoba-Cadahia, Carlos Gómez-Gómez, J. Gonzalo. Ustekinumab is effective and safe in the treatment of Crohn’s disease refractory to anti-TNFα in an orthotopic liver transplant patient. Journal of Crohn's and Colitis 2015; 816–817 DOI: 10.1093/ecco-jcc/jjv109).
25. Merchea A, Shahjehan F, Croome KP, et al. colorectal cancer characteristics and outcomes after solid organ transplantation. Journal of Oncology 2019; 2018: 1-8 [PMID 30941176 DOI: 10.1155/2019/5796108]
26. Noone AM, Pfeiffer RM, Dorgan JF, et al. Cancer-attributable mortality among solid organ transplant recipients in The United States: 1987 trough 2014. Cancer 2019; 125: 2647-2655 [PMID 31034602 DOI: 10.10027cncr.32136]
27. Safaeian M, Robbins HA, Berndt SI, et al. Risk of colorectal cancer after solid organ transplantation in the United States. American Journal of Transplantation 2016; 16: 960-967 [PMID 26731613 DOI: 10.1111/ajt13549
28. Singh S, Varayil J, E Loftus EV Jr, et al. Incidence of colorectal cancer after liver transplantation for primary sclerosing cholangitis: a systematic review and meta-analysis. Liver Transpl. 2013; 19:1361–1369 [PMID: 24019127 DOI:10.1002/lt.23741]
29. Rao BB, Lashner B, Kowdley KV. Reviewing the Risk of Colorectal Cancer in Inflammatory Bowel Disease After Liver Transplantation for Primary Sclerosing Cholangitis. Inflammatory Bowel Dis 2018 24:269-276 [PMID: 29361103 doi: 10.1093/ibd/izx056]
30. Shah SC, Joren R, Castaneda D, et al. High Risk of advanced colorectal neoplasia in patients with primary sclerosing cholangitis associated with inflammatory bowel disease. Clinical Gastroenterology and Hepatology 2018; 16: 1106-1113 [PMID: 29378311
DOI: 10.1016/j.cgh.2018.01.023]
Related articles

Digestive Diseases Image

Spontaneous regression of a rectal cancer

DOI: 10.17235/reed.2023.9486/2023

Letter

Hepatosplenic T-cell lymphoma and inflammatory bowel disease

DOI: 10.17235/reed.2023.9472/2023

Letter

Vaginal lesion as first manifestation of colorectal disease

DOI: 10.17235/reed.2022.9270/2022

Review

Clinical settings with tofacitinib in ulcerative colitis

DOI: 10.17235/reed.2022.8660/2022

Digestive Diseases Image

Posterior reversible encephalopathy syndrome (PRES) in post liver transplantation

DOI: 10.17235/reed.2022.8694/2022

Letter

Ertapenem neurotoxicity in liver transplantation

DOI: 10.17235/reed.2021.8469/2021

Letter

Anal neoplasia and perianal Crohn’s disease: myth or reality?

DOI: 10.17235/reed.2021.8317/2021

Letter

Apoptotic colopathy as a manifestation of Good’s syndrome

DOI: 10.17235/reed.2021.8297/2021

Original

Radon exposure and inflammatory bowel disease in a radon prone area

DOI: 10.17235/reed.2021.8239/2021

Digestive Diseases Image

Percutaneous treatment of a splenorenal shunt with an atrial septal closure device

DOI: 10.17235/reed.2020.7701/2020

Review

Physical frailty in liver transplantation

DOI: 10.17235/reed.2020.7448/2020

Review

New non-invasive biomarkers for colorectal cancer screening

DOI: 10.17235/reed.2020.7233/2020

Letter

Management of hepatic artery aneurysms

DOI: 10.17235/reed.2020.7219/2020

Digestive Diseases Image

Epithelioid hemangioendothelioma: a rare cause of a liver tumor

DOI: 10.17235/reed.2020.7127/2020

Editorial

Is celiac disease really associated with inflammatory bowel disease?

DOI: 10.17235/reed.2019.6779/2019

Letter

Medullary colorectal carcinoma. Do we really know it?

DOI: 10.17235/reed.2020.6728/2019

Original

Megacolon in inflammatory bowel disease: response to infliximab

DOI: 10.17235/reed.2020.6394/2019

Letter

Hepatocyte transplantation

DOI: 10.17235/reed.2019.6270/2019

Review

Psoriasis and fatty liver: a harmful synergy

DOI: 10.17235/reed.2019.6263/2019

Editorial

Diet in the etiology of inflammatory bowel disease

DOI: 10.17235/reed.2018.6119/2018

Letter

The rectosigmoid junction: are limits important?

DOI: 10.17235/reed.2019.5983/2018

Case Report

Serrated Lesions in patients with Inflammatory Bowel Disease.

DOI: 10.17235/reed.2019.5910/2018

Editorial

Colorectal cancer screening and survival

DOI: 10.17235/reed.2018.5870/2018

Editorial

Lung transplantation and esophageal dysfunction

DOI: 10.17235/reed.2018.5693/2018

Editorial

Online social networks and inflammatory bowel disease

DOI: 10.17235/reed.2018.5496/2018

Letter to the Editor

Post-transplant lymphoproliferative disease after liver transplantation

DOI: 10.17235/reed.2017.5387/2017

Letter to the Editor

Idiopathic portal hypertension with regard to thiopurine treatment

DOI: 10.17235/reed.2018.5256/2017

Editorial

Specialist care in the management of inflammatory bowel disease

DOI: 10.17235/reed.2016.4628/2016

Letter to the Editor

Liver metastasis from colorectal cancer 12 years after liver transplantation

DOI: 10.17235/reed.2017.4507/2016

Review

Serrated lesions and serrated polyposis syndrome

DOI: 10.17235/reed.2017.4065/2015

Letter to the Editor

Endobronchial metastases of colorectal cancer

DOI: 10.17235/reed.2016.4080/2015

Citation tools
Martínez Montiel M, Casis Herce B. Inflammatory bowel disease and solid organ transplantation. 7361/2020


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1456 visits.
This article has been downloaded 437 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 22/06/2020

Accepted: 29/07/2020

Online First: 25/11/2020

Published: 11/01/2021

Article revision time: 19 days

Article Online First time: 156 days

Article editing time: 203 days


Share
This article has been rated by 2 readers.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology