Year 2018 / Volume 110 / Number 12
Letter
Crohn’s disease and cystic fibrosis: there is still a lot to learn

835-836

DOI: 10.17235/reed.2018.5725/2018

Claudio Trigo Salado, Eduardo Leo Carnerero, María Dolores de la Cruz Ramírez,

Abstract
The relationship between cystic fibrosis (CF) and the risk of developing inflammatory bowel disease (IBD) is not clear. CFTR mutations can influence dysbiosis and increased intestinal permeability, which are two key elements in the pathophysiology of IBD. These patients have increased intestinal inflammation, as demonstrated by increase pro-inflammatory gene expression in the bowel, specific fecal markers (fecal calprotectin), gross lesions (capsule endoscopy) and histological lesions on examination of surgical specimens.
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References
1- Garg, M. & Ooi, C.Y. The enigmatic gut in cystic fibrosis: linking inflammation, dysbiosis, and the increased risk of malignancy. Curr Gastroenterol Rep (2017) 19: 6. https://doi.org/10.1007/s11894-017-0546-0
2- Bresso F, et al. Potential Role for the Common Cystic Fibrosis F508 Mutation in Crohn’s Disease . Inflamm Bowel Dis 2007;13:531–536
3- Bahmanyar, Shahram et al. Cystic fibrosis gene mutations and gastrointestinal diseases J Cyst Fibros, 9 (2010), Jul;9(4):288-91
4- Jambhekar SK, Carroll JL, Keiles S. Report of two patients with associated conditions in addition to cystic fibrosis.
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Trigo Salado C, Leo Carnerero E, de la Cruz Ramírez M. Crohn’s disease and cystic fibrosis: there is still a lot to learn . 5725/2018


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Publication history

Received: 13/05/2018

Accepted: 29/06/2018

Online First: 21/09/2018

Published: 03/12/2018

Article Online First time: 131 days

Article editing time: 204 days


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