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1.Wallach D, Kang T B, Dillon C P, et al. Programmed necrosis in inflammation: Toward identification of the effector molecules. Science 2016; 352(6281):aaf2154. DOI: 10.1126/science.aaf2154.
2.Walle L V, Lamkanfi M. Pyroptosis. Current Biology 2016;26(13):R568-R572. DOI: 10.1016/j.cub.2016.02.019.
3.Till S, Jorge H M, Eran E, et al. Inflammasomes in health and disease. Nature 2012; 481(7381):278-86. DOI: 10.1038/nature10759.
4.Szabo G, Csak T. Inflammasomes in liver diseases. Journal of Hepatology 2012; 57(3):642-4. DOI: 10.1016/j.jhep.2012.03.035.
5.Lebeaupin C, Proics E, Bieville C H D D, et al. ER stress induces NLRP3 inflammasome activation and hepatocyte death. Cell Death & Disease 2015;6(9):e1879. DOI: 10.1038/cddis.2015.248.
6.Miura K, Kodama Y, Inokuchi S, et al. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology 2010; 139(1):323-334.e7. DOI: 10.1053/j.gastro.2010.03.052.
7.Broz P. Immunology: Caspase target drives pyroptosis. Nature2015; 526(7575):642-3. DOI: 10.1038/nature15632.
8.He Y, Hara H, Núñez G. Mechanism and Regulation of NLRP3 Inflammasome Activation. Trends in Biochemical Sciences 2016;41(12):1012. DOI: 10.1016/j.tibs.2016.09.002.
9.Yang D, He Y, Muñozplanillo R, et al. Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock. Immunity 2015;43(5):923-32. DOI: 10.1016/j.immuni.2015.10.009.
10.Schroder K, Tschopp J. The inflammasomes. Cell 2010;140(6):821-32. DOI: 10.1016/j.cell.2010.01.040.
11.Kayagaki N, Stowe I B, Lee B L, et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 2015; 526(7575):666-71. DOI: 10.1038/nature15541.
12.Ding J, Wang K, Liu W, et al. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature 2016;535(7610):111. DOI: 10.1038/nature18590.
13.Xing L, Zhang Z, Ruan J, et al. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature 2016;535(7610):153. DOI: 10.1038/nature18629.
14.Henaomejia J, Elinav E, Jin C C, et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012; 482(7384):179-85. DOI: 10.1038/nature10809.
15.Á GonzálezRodríguez, Mayoral R, Agra N, et al. Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. Cell Death & Disease 2014;5(e1179):e1179. DOI: 10.1038/cddis.2014.162.
16.Vandanmagsar B, Youm Y H, Ravussin A, et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nature Medicine 2011; 17(2):179-88. DOI: 10.1038/nm.2279.
17.Stienstra R, van Diepen J A, Tack C J, et al. Inflammasome is a central player in the induction of obesity and insulin resistance. Proc Natl Acad Sci U S A 2011; 108(37):15324-9. DOI: 10.1073/pnas.1100255108.
18.Mridha A R, Wree A, Robertson A A, et al. "NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice". Journal of Hepatology 2017; 66(5):1037. DOI: 10.1016/j.jhep.2017.01.022.
19.Xu B, Jiang M, Chu Y, et al. Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice. J Hepatology 2018;68(4):773-82. DOI: 10.1016/j.jhep.2017.11.040.
20.Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 2011;141(5):1572-85. DOI: 10.1053/j.gastro.2011.09.002.
21.Mandrekar P, Bataller R, Tsukamoto H, et al. ALCOHOLIC HEPATITIS: TRANSLATIONAL APPROACHES TO DEVELOP TARGETED THERAPIES. Hepatology 2016;64(4):1343. DOI: 10.1002/hep.28530.
22.Sugimoto K, Takei Y. Pathogenesis of alcoholic liver disease. Hepatology Research the Official Journal of the Japan Society of Hepatology 2017;47(1):70. DOI: 10.1111/hepr.12736.
23. Petrasek J, Irachetavellve A, Saha B, et al. Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease. J Leukoc Biol 2015; 98(2):249-56. DOI: 10.1189/jlb.3AB1214-590R.
24.Georgiana B S, Erawan B K, Lidia T, et al. Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease. Journal of Inflammation 2012;9(1):49. DOI: 10.1186/1476-9255-9-49.
25.Khanova E, Wu R, Wang W, et al. Pyroptosis by Caspase11/4‐Gasdermin‐D Pathway in Alcoholic Hepatitis. Hepatology 2017;33(9):1206. DOI: 10.1002/hep.29645.
26.Luan J, Zhang X, Wang S, et al. NOD-Like Receptor Protein 3 Inflammasome-Dependent IL-1β Accelerated ConA-Induced Hepatitis. Frontiers in Immunology 2018;9:758. DOI: 10.3389/fimmu.2018.00758.
27.Chen W, Lu F, Ye W, et al. Study on liver damage and pyroptosis of autoimmune hepatitis by high-fat diet. Chinese Journal of Infectious Diseases 2018(1).
28.Mohd H K, Groeger J, Flaxman A D, et al. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology 2013; 57(4):1333-42. DOI: 10.1002/hep.26141.
29.Chen W, Xu Y, Li H, et al. HCV Genomic RNA Activates the NLRP3 Inflammasome in Human Myeloid Cells. Plos One 2014;9(1):e84953. DOI: 10.1371/journal.pone.0084953.
30.Kofahi H M, Taylor N G A, Hirasawa K, et al. Hepatitis C Virus Infection of Cultured Human Hepatoma Cells Causes Apoptosis and Pyroptosis in Both Infected and Bystander Cells. Scientific Reports 2016, 6:37433. DOI: 10.1038/srep37433.
31.Wang Y, Gong Z. Regulation of acetylation and pyroptosis during liver failure. World Chinese Journal of Digestion 2018(11).
32.Wang J, Ren H, Yuan X, et al. IL - 10 secreted by Mesenchymal stem cells attenuates acute liver failure through inhibiting pyroptosis. Hepatology Research 2018;48(3). DOI: 10.1111/hepr.12969.
33.Wree A, Eguchi A, Mcgeough M D, et al. NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology 2014; 59(3):898-910. DOI: 10.1002/hep.26592.
34.Huang C, Yu W, Cui H, et al. P2X7 blockade attenuates mouse liver fibrosis. Molecular Medicine Reports 2014;9(1):57-62. DOI: 10.3892/mmr.2013.1807.
35.Dixon L J, Flask C A, Papouchado B G, et al. Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis. Plos One 2013;8(2):e56100. DOI: 10.1371/journal.pone.0056100.
36.Kamari Y, Shaish A, Vax E, et al. Lack of Interleukin-1α or Interleukin-1β Inhibits Transformation of Steatosis to Steatohepatitis and Liver Fibrosis in Hypercholesterolemic Mice. Journal of Hepatology 2011;55(5):1086-94. DOI: 10.1016/j.jhep.2011.01.048.
37.Wang C, Wang X, Su Z, et al. The novel mTOR inhibitor Torin-2 induces autophagy and downregulates the expression of UHRF1 to suppress hepatocarcinoma cell growth. Oncology Reports 2015;34(4):1708-16. DOI: 10.3892/or.2015.4146.
38.Xiaofeng Sun, Lihui Han, Seth P, et al. Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/Entpd1, null Mice. Hepatology 2013, 57(1):205-16. DOI: 10.1002/hep.25989.
39.Ma X. Effect and molecular mechanism of AIM2 on hepatocellular carcinoma. Shandong University 2016.
40.Yip N K, Ho W S. Berberine induces apoptosis via the mitochondrial pathway in liver cancer cells. Oncology Reports 2013;30(3):1107-12. DOI: 10.3892/or.2013.2543.
41.Chu Q, Jiang Y, Wei Z, et al. Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma. Oncotarget 2016;7(51):84658. DOI: 10.18632/oncotarget.12384.
42.Wang J, GUO X. Relationship among pyroptosis.inflammasome and tumor 2016;V43(9): 676-80.
43.Yan W, Chang Y, Liang X, et al. High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases. Hepatology 2012;55(6):1863-75. DOI: 10.1002/hep.25572.