Year 2021 / Volume 113 / Number 4
Review
Pyroptosis in liver disease

280-285

DOI: 10.17235/reed.2020.7034/2020

Lijuan Zhang, Wang Zeyu, Binghua Liu, Shihe Jang, Zhiguang Zhang, Yong Jiang,

Abstract
Pyroptosis is an inflammatory cell death process that is dependent on caspase. Pyroptosis is a specific form of programmed cell death with the morphological characteristics of formation of pores on the cell membrane, cell swelling, and rupture of the plasma membrane. Recent studies have demonstrated that pyroptosis plays an important role in the occurrence and development of liver diseases. Here, we focus on the mechanisms of pyroptosis, as well as on the relationship between pyroptosis and liver diseases.
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References
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38.Xiaofeng Sun, Lihui Han, Seth P, et al. Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/Entpd1, null Mice. Hepatology 2013, 57(1):205-16. DOI: 10.1002/hep.25989.
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40.Yip N K, Ho W S. Berberine induces apoptosis via the mitochondrial pathway in liver cancer cells. Oncology Reports 2013;30(3):1107-12. DOI: 10.3892/or.2013.2543.
41.Chu Q, Jiang Y, Wei Z, et al. Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma. Oncotarget 2016;7(51):84658. DOI: 10.18632/oncotarget.12384.
42.Wang J, GUO X. Relationship among pyroptosis.inflammasome and tumor 2016;V43(9): 676-80.
43.Yan W, Chang Y, Liang X, et al. High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases. Hepatology 2012;55(6):1863-75. DOI: 10.1002/hep.25572.
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Publication history

Received: 07/03/2020

Accepted: 14/07/2020

Online First: 25/11/2020

Published: 07/04/2021

Article revision time: 124 days

Article Online First time: 263 days

Article editing time: 396 days


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