Year 2016 / Volume 108 / Number 10
Case Report
Glycogenic hepatopathy in young adults: a case series

673-676

DOI: 10.17235/reed.2016.3934/2015

Marco Silva, Margarida Marques, Hélder Cardoso, Susana Rodrigues, Patrícia Andrade, Armando Peixoto, Joana Pardal, Joanne Lopes, Fátima Carneiro, Guilherme Macedo,

Abstract
Glycogenic hepatopathy is a rare and under-recognized complication in long-standing poorly controlled type 1 diabetes mellitus patients. This is a distinct entity from other causes of hepatomegaly and elevated liver enzymes in diabetics, such as nonalcoholic fatty liver disease. Glycogenic hepatopathy is characterized by the combination of poorly controlled diabetes, acute liver injury with marked elevation in serum aminotransferases, and the characteristic histological features on liver biopsy. It is important to distinguish this entity as it has the potential for resolution following improved glycemic control. In this report, we describe four cases of adult patients presenting elevated serum transaminases and hepatomegaly with a history of poorly controlled type I diabetes mellitus. One of the patients had also elevated amylase and lipase in the serum, without clinical or imagiologic evidence of acute pancreatitis (AP). Liver biopsy was performed in all patients and revealed glycogenic hepatopathy. Clinician’s awareness of glycogenic hepatopathy should prevent diagnostic delay or misdiagnosis and will provide better insight and management for this condition.
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References
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Silva M, Marques M, Cardoso H, Rodrigues S, Andrade P, Peixoto A, et all. Glycogenic hepatopathy in young adults: a case series. 3934/2015


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Publication history

Received: 19/07/2015

Accepted: 16/09/2015

Online First: 22/02/2016

Published: 30/09/2016

Article revision time: 58 days

Article Online First time: 218 days

Article editing time: 439 days


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