Year 2022 / Volume 114 / Number 6
Original
Participation in clinical trials increases the detection of pre-malignant lesions during colonoscopy

323-328

DOI: 10.17235/reed.2021.8104/2021

Alexandre Oliveira Ferreira, Maria Pia Costa-Santos, Catarina Gomes, Bárbara Morão, Luisa Glória, Marília Cravo, Mário Dinis-Ribeiro, Jorge Canena,

Abstract
Background: colorectal adenoma detection has been associated with the effectiveness of cancer prevention. Clinical trials have been designed to determine the role of several interventions to increase the detection of pre-malignant lesions. We hypothesized that colonoscopy in the setting of clinical trials has a higher pre-malignant lesion detection rate. Methods: a cross-sectional study was performed that compared the detection of pre-malignant lesions in 147 randomly sampled non-research colonoscopies and 294 from the control group of two prospective trials. Outpatients aged 40-79 years, with no personal history of colorectal cancer (CRC) were included. Results: baseline characteristics were similar between the two groups. The pre-malignant lesion detection rate in the trial vs control group was 65.6 % vs 44.2 % (OR 2.411; 95 % CI: 1.608-3.614; p < 0.001), the polyp detection rate was 73.8 % vs 59.9 % (OR 1.889; 95 % CI: 1.242-2.876; p = 0.003), the adenoma detection rate was 62.6 % vs 44.2 % (OR 2.110; 95 % CI: 1.411-3.155; p < 0.001) and the sessile serrated lesion detection rate was 17 % vs 4.1 % (OR 4.816; 95 % CI: 2.014-11.515; p < 0.001). The mean number of pre-malignant and sessile serrated lesions was 1.70 vs 1.06 (p = 0.002) and 0.32 vs 0.06 (p = 0.001) lesions per colonoscopy, respectively. There was no significant change in any of the study outcomes according to the multivariate analysis with each single potential confounder. Conclusions: patients involved in colonoscopy trials may benefit from higher quality examinations, as shown by the higher detection rates. Institutions should consider supporting clinical research in colonoscopy as a simple means to improve colonoscopy quality and colorectal cancer prevention.
Share Button
New comment
Comments
No comments for this article
Related articles

Digestive Diseases Image

Underwater polypectomy at the appendiceal orifice in a patient on anticoagulation

DOI: 10.17235/reed.2023.9842/2023

Letter

An uncommon colonic polyp

DOI: 10.17235/reed.2022.9160/2022

Digestive Diseases Image

Intestinal obstruction due to bariolith impaction

DOI: 10.17235/reed.2022.9084/2022

Letter

Anorectal malignant melanoma, a diagnostic challenge

DOI: 10.17235/reed.2022.9068/2022

Letter

Lead ingestion, medical emergency and action plan

DOI: 10.17235/reed.2022.9048/2022

Letter

Endoscopic findings of radiation ileitis

DOI: 10.17235/reed.2022.9036/2022

Digestive Diseases Image

Steatotic hepatocellular adenoma: an unusual cause of a hypermetabolic liver lesion

DOI: 10.17235/reed.2022.9026/2022

Letter

Endoscopic imaging of pneumatosis intestinalis

DOI: 10.17235/reed.2022.8972/2022

Editorial

Colonoscopy — When quality matters

DOI: 10.17235/reed.2022.8942/2022

Letter

Analysis of retracted articles in the field of Gastroenterology

DOI: 10.17235/reed.2022.8760/2022

Digestive Diseases Image

Colonic Kaposi’s sarcoma as the first clinical manifestation of undiagnosed HIV

DOI: 10.17235/reed.2022.8717/2022

Letter

Gastrointestinal lymphoma, a rare endoscopic lesion

DOI: 10.17235/reed.2022.8555/2021

Letter

Cecal MALT lymphoma: a challenging diagnosis

DOI: 10.17235/reed.2021.8526/2021

Letter

Brunneroma: an infrequent duodenal neoplasm

DOI: 10.17235/reed.2021.8349/2021

Letter

Surprises in cecal intubation: foreign bodies in the colon

DOI: 10.17235/reed.2021.8155/2021

Letter

Mucinous cystadenoma arising from a pancreatic heterotopia

DOI: 10.17235/reed.2020.7486/2020

Digestive Diseases Image

Phlebosclerotic colitis: an unusual cause of abdominal pain and hematochezia

DOI: 10.17235/reed.2020.7358/2020

Review

New non-invasive biomarkers for colorectal cancer screening

DOI: 10.17235/reed.2020.7233/2020

Special Article

Quality indicators in enteroscopy. Enteroscopy procedure

DOI: 10.17235/reed.2020.6946/2020

Letter

Colonic adenocarcinoma arising from traditional serrated adenoma

DOI: 10.17235/reed.2020.6818/2019

Case Report

Primary colon mantle lymphoma: a misleading macroscopic appearance!

DOI: 10.17235/reed.2019.6405/2019

Special Article

The quality of abdominal ultrasound: a much-needed consensus

DOI: 10.17235/reed.2019.6177/2019

Letter

Gastric serrated adenoma

DOI: 10.17235/reed.2019.6145/2018

Digestive Diseases Image

Colorectal penetration by two intrauterine devices

DOI: 10.17235/reed.2019.5974/2018

Editorial

Colorectal cancer screening and survival

DOI: 10.17235/reed.2018.5870/2018

Letter

Bacterial endogenous endophthalmitis after colonoscopy

DOI: 10.17235/reed.2018.5658/2018

Letter

Giant hepatobiliary cystadenoma: clinic-pathological findings

DOI: 10.17235/reed.2018.5414/2017

Review

Quality indicators in colonoscopy. The colonoscopy procedure

DOI: 10.17235/reed.2018.5408/2017

Letter to the Editor

A rare complication after colonoscopy: a splenic rupture

DOI: 10.17235/reed.2018.5362/2017

Letter to the Editor

Acute appendicitis after a colonic endoscopic submucosal resection

DOI: 10.17235/reed.2018.5307/2017

Digestive Diseases Image

Contribution of the virtual colonoscopy in a case of intestinal intussusception

DOI: 10.17235/reed.2017.5261/2017

Digestive Diseases Image

A bull horn fragment found on colonoscopy

DOI: 10.17235/reed.2017.5020/2017

Letter to the Editor

Propofol sedation Quality and safety. Failure mode and effects analysis.

DOI: 10.17235/reed.2017.4976/2017

Editorial

Issue pending: minimizing anxiety before colonoscopy

DOI: 10.17235/reed.2016.4756/2016

Digestive Diseases Image

Intrauterine device in the rectal cavity

Original

Coping with celiac disease: how heavy is the burden for caregivers?

DOI: 10.17235/reed.2017.4518/2016

Letter to the Editor

Primary chancre in the rectum: an underdiagnosed cause of rectal ulcer

DOI: 10.17235/reed.2017.4457/2016

Digestive Diseases Image

Pneumatosis cystoides intestinalis

Review

Endoscopic ampullectomy: a technical review

DOI: 10.17235/reed.2016.3867/2015

Letter to the Editor

Splenic rupture after colorectal cancer screening

DOI: 10.17235/reed.2015.3714/2015

Letter to the Editor

Mucinous hepatic cystic neoplasm: An uncommon cystic lesion in the liver

DOI: 10.17235/reed.2015.3698/2015

Citation tools
Ferreira A, Costa-Santos M, Gomes C, Morão B, Glória L, Cravo M, et all. Participation in clinical trials increases the detection of pre-malignant lesions during colonoscopy. 8104/2021


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1938 visits.
This article has been downloaded 90 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 15/05/2021

Accepted: 26/09/2021

Online First: 05/10/2021

Published: 07/06/2022

Article revision time: 104 days

Article Online First time: 143 days

Article editing time: 388 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology