Year 2024 / Volume 116 / Number 1
Letter
Amyloidosis: a rare cause of severe acute liver failure

44-45

DOI: 10.17235/reed.2023.9598/2023

Daniel Alvarenga Fernandes, Guilherme Rossi Assis-Mendoça, Larissa Bastos Eloy da Costa, Leandro Luiz Lopes de Freitas, Ilka de Fátima Ferreira Santana Boin, Fabiano Reis,

Abstract
Gastrointestinal amyloidosis can be primary, more associated with monoclonal plasma cell dyscrasia, or secondary, usually secondary to a tissue-destructive, chronic inflammatory process (such as inflammatory bowel disease, for example) and long-term dialysis. The rare presentation of severe acute liver failure in systemic amyloidosis can make this diagnosis/ management more difficult. Hepatomegaly with signs of diffuse infiltrative disease and periportal involvement associated with thoracic and other abdominal radiological findings in the appropriate clinical context may constitute a diagnostic imaging clue in this challenge.
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References
1. Loudin M, Childers R, Zivony A, et al. Liver failure secondary to amyloid light-chain amyloidosis. Am J Med. 2016;129(4):19-20.
2. Bolufer CS, Polo IO, Adrián JCG. Liver failure caused by Kappa-light chain amyloidosis: a rare case report of multiple myeloma. Rev Esp Enferm Dig 2020:112(10):814-815.
3. Bimbato EM, Carvalho AG, Reis F. Toxic and metabolic encephalopathies: iconographic essay. Radiol Bras. 2015;48(2):121-5.
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5. Dias E, Cardoso H, Marques M, et al. Hepatic amyloidosis: a prevalence study and clinical characterization of a rare and severe disease. Rev Esp Enferm Dig 2023:115(1):16-21.
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Citation tools
Fernandes D, Assis-Mendoça G, Costa L, Freitas L, Boin I, Reis F, et all. Amyloidosis: a rare cause of severe acute liver failure. 9598/2023


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Publication history

Received: 15/03/2023

Accepted: 15/03/2023

Online First: 28/03/2023

Published: 11/01/2024

Article Online First time: 13 days

Article editing time: 302 days


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