Year 2024 / Volume 116 / Number 8
Letter
Persistently elevated alkaline phosphatase without hepatopathy? Literature review

447-448

DOI: 10.17235/reed.2023.9972/2023

Flor M. Fernández-Gordón Sánchez, Celia Gómez Labrador, Daniel Riado Mínguez, Sandra Agudo Fernández, Carlos Castaño Milla,

Abstract
Elevated alkaline phosphatase (ALP) levels are found in multiple hepatobiliary diseases and in bone diseases. ALP can also originate in the intestine and placenta. Very few cases of persistent elevations of IALP or in the context of benign familial intestinal hyperphosphatasemia (BFIH) without underlying pathology have been reported in the literature. In the evaluation of elevated ALP, most patients will not require determination of its isoenzymes. However, it is important to be aware of this entity to avoid unnecessary additional studies and to establish the diagnosis of a persistent but benign biochemical abnormality.
Share Button
New comment
Comments
No comments for this article
References
1 Verma J, Gorard DA. Persistently elevated alkaline phosphatase. BMJ Case Rep. 2012;2012:bcr2012006768. Published 2012 Aug 24. doi:10.1136/bcr-2012-006768
2 Chauhan M, Alpers DH, Hamilton JP, Thuluvath PJ. If Hoofbeats are not From Horses, It Could be Zebras!! Isolated Hyper-alkaline Phosphatasemia. J Clin Exp Hepatol. 2021;11(5):619-622. doi:10.1016/j.jceh.2020.12.001
3 Prevalence and Clinical Significance of Intestinal Alkaline Phosphatase in Healthy Adults. Ann Lab Med 2004;24:87-90
4 Carrascosa C et al. Hyperphosphatasemia familiar de origen intestinal [Familial hyperphosphatasemia of intestinal origin]. Rev Esp Enferm Dig. 1995;87:327-9
5 Panteghini M. Benign inherited hyperphosphatasemia of intestinal origin: report of two cases and a brief review of the literature. Clin Chem. 1991;37(8):1449-1452
Related articles
Citation tools
Fernández-Gordón Sánchez F, Gómez Labrador C, Riado Mínguez D, Agudo Fernández S, Castaño Milla C. Persistently elevated alkaline phosphatase without hepatopathy? Literature review. 9972/2023


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 646 visits.
This article has been downloaded 180 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 20/09/2023

Accepted: 25/09/2023

Online First: 26/10/2023

Published: 01/08/2024

Article Online First time: 36 days

Article editing time: 316 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology