Year 2018 / Volume 110 / Number 11
Case Report
Topical mesalazine as a cause of Stevens-Johnson syndrome

736-738

DOI: 10.17235/reed.2018.5429/2017

Andrea Núñez Ortiz, Claudio Trigo Salado, María Dolores de la Cruz Ramírez, José Manuel Herrera Justiniano, Eduardo Leo Carnerero,

Abstract
Mesalazine is a drug routinely used in ulcerative colitis and usually has few side effects. There have been reports of uncommon cases of severe mucocutaneous damage, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), induced by salicylates. It is important to diagnose these promptly due to the high morbidity and mortality rates. We describe the case of a 46-year-old female with ulcerative proctitis, who developed SJS following topical mesalazine use. The lesions responded well to intravenous corticosteroids after discontinuation of the drug.
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References
[1] Erythroderma and toxic epidermal necrolysis caused by to 5-aminosalacylic acid. Lemoli E, Piconi S, Ardizzone S. Inflamm Bowel Dis. 2006 Oct; 12(10):1007-8.
[2] Toxic epidermal necrosis associated with mesalamine in a patient with ulcerative colitis. Fukunaga K, Ohda Y, Inoue T. Inflamm Bowel Dis. 2007 Aug; 13 (8):1055-6.
[3] U.K. guidelines for the management of Stevens–Johnson syndrome/toxic epidermal necrolysis in adults 2016. Creamer D, Walsh SA, Dziewulski P. Br J Dermatol. 2016 Jun; 174 (6):1194-227.
[4] Toxic epidermal necrolysis: Part I. Introduction, history, clinical features, systemic manifestations, etiology and inmunopathogenesis. Schwartz RA, McDonough PH, Lee BW. J Am Acad Dermatol. 2013 Aug; 69 (2):173 e1-13.
[5] Toxic epidermal necrolysis: Part I. Prognosis, sequelae, diagnosis, differential diagnosis, prevention, and treatment. Schwartz RA, McDonough PH, Lee BW. J Am Acad Dermatol.J Am Acad Dermatol. 2013 Aug; 69 (2):187 e1-16.
[6] Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Standard Reporting and Evaluation Guidelines: Results of a National Institutes of Health Working Group. Maverakis E, Wang EA, Shinkai K. JAMA Dermatol. 2017 Mar 15.
[7] Síndrome de Stevens-Johnson y necrólisis epidérmica tóxica: revisión de la experiencia clínica en un Hospital Universitario (1989-2008). Ferrándiz-Pulido C, García-Fernández D, Gómez-Morel P. Med Clin 2011; 136 (13):583–587.
[8] ALDEN, an algorithm for assessment of drug causality in Stevens-Johnson Syndrome and toxic epidermal necrolysis: comparison with case-control analysis. Sassolas B, Haddad C, Mockenhaupt M. Clin Pharmacol Ther. 2010 Jul; 88 (1): 60-8
[9] Stevens–Johnson syndrome with sulfasalazine treatment: Report of two cases. Tremblay L, Pineton de Chambrun G, De Vroey B. J Crohns Colitis. 2011 Oct; 5 (5): 457-60.
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Núñez Ortiz A, Trigo Salado C, de la Cruz Ramírez M, Herrera Justiniano J, Leo Carnerero E. Topical mesalazine as a cause of Stevens-Johnson syndrome. 5429/2017


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Publication history

Received: 17/12/2017

Accepted: 29/04/2018

Online First: 22/06/2018

Published: 30/10/2018

Article revision time: 92 days

Article Online First time: 187 days

Article editing time: 317 days


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