Year 2022 / Volume 114 / Number 3
Letter
Acute esophageal necrosis induced by immune checkpoint inhibitors

182-183

DOI: 10.17235/reed.2021.8418/2021

Luis Figuero Pérez, Alejandro Olivares-Hernández, Arantzazu Amores-Martín, Juan Jesús Cruz-Hernández, Emilio Fonseca-Sánchez,

Abstract
A 73-year-old male with a history of chronic obstructive pulmonary disease and stage IV lung adenocarcinoma, being treated with the PD-1 inhibitor nivolumab, presented to the Emergency Room with a two-day history of coffee ground emesis and melena. On examination, he was tachycardic (130 per minute) and hypotensive (95/55 mmHg). Laboratory studies revealed anemia (6.9 g/dl), leukocytosis and hyper-lactatemia (lactate 6.3 mmol/l). Esophagogastroduodenoscopy was performed which showed diffuse circumferential blackish, necrotic-appearing mucosa of the first third of the esophagus. These findings were consistent with a diagnosis of acute esophageal necrosis (AEN). A biopsy of the esophageal mucosa demonstrated fragments of necrotic tissue with predominant lymphocyte infiltration. He was managed with a strict restriction of oral intake, total parenteral nutrition, double-dose proton pump inhibitors and broad-spectrum antibiotics (piperacillin/tazobactam). Despite the measures adopted, the patient presented a progressive clinical deterioration and died of multiple organ failure 12 days after admission.
Share Button
New comment
Comments
No comments for this article
Citation tools
Figuero Pérez L, Olivares-Hernández A, Amores-Martín A, Cruz-Hernández J, Fonseca-Sánchez E. Acute esophageal necrosis induced by immune checkpoint inhibitors. 8418/2021


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1090 visits.
This article has been downloaded 160 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 25/10/2021

Accepted: 11/11/2021

Online First: 16/11/2021

Published: 07/03/2022

Article revision time: 15 days

Article Online First time: 22 days

Article editing time: 133 days


Share
This article has been rated by 1 readers.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology