Year 2020 / Volume 112 / Number 6
Letter
Pancreatic metastasis of Merkel-cell carcinoma: a rare neoplasm of the pancreas

506-507

DOI: 10.17235/reed.2020.6467/2019

José Francisco Sánchez Melgarejo, María Josefa Sánchez Fernández, Eduardo Alcaraz Mateos,

Abstract
Only 2-3.9% of pancreatic malignancies represent metastases from other sites, the most common origins being the lungs, kidneys, and gastrointestinal tract. Differentiating between primary and secondary lesions may be challenging with imaging techniques but EUS-guided FNA is a safe, accurate procedure for obtaining a tissue diagnosis. We report the case of a 70-year-old male who, following satisfactory treatment for a Merkel-cell carcinoma in the right groin, presented with jaundice and an indurated, vascularized, adherent nodule on the right thigh. Endoscopic ultrasound identified a mass at the pancreatic head as well as a perilesional adenopathy with no evidence of vascular involvement. FNA revealed cell proliferation, which was immunohistochemically positive for CD56, synaptophysin, and chromogranin, these findings being consistent with poorly-differentiated neuroendocrine carcinoma. Given the patient's history we considered this lesion to be a pancreatic metastasis of Merkel-cell carcinoma, which represents a rare finding.
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References
1. Betés M, González Vázquez S, Bojórquez A, et al. Metastatic tumors in the pancreas: the role of endoscopic ultrasound-guided fine-needle aspiration. Rev Española Enfermedades Dig. 2019 May;111(5):345–50.
2. De Cock E, Remery M, De Vuyst M, et al. An unusual neoplasm of the pancreas: Pancreatic metastasis of a Merkel cell carcinoma. Case report and review of the literature. Acta Gastroenterol Belg. 78(3):332–5.
3. García García de Paredes A, Tavío Hernández E, Foruny Olcina JR, et al. Metástasis pancreática de carcinoma de células de Merkel diagnosticada mediante biopsia guiada por ecoendoscopia. Gastroenterol Hepatol. 2016 Jun;39(6):395–7.
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Sánchez Melgarejo J, Sánchez Fernández M, Alcaraz Mateos E. Pancreatic metastasis of Merkel-cell carcinoma: a rare neoplasm of the pancreas. 6467/2019


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Publication history

Received: 26/06/2019

Accepted: 03/07/2019

Online First: 07/05/2020

Published: 08/06/2020

Article Online First time: 316 days

Article editing time: 348 days


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