Year 2023 / Volume 115 / Number 12
Original
Value of CRP/albumin ratio as a prognostic marker of acute pancreatitis: a retrospective study

707-712

DOI: 10.17235/reed.2023.9345/2022

Jean Félix Piñerúa-Gonsálvez, María Lourdes Ruiz Rebollo, Rosanna del Carmen Zambrano-Infantino, María Antonella Rizzo-Rodríguez, Luis Fernández-Salazar,

Abstract
Introduction: the C-reactive protein (CRP) to albumin ratio is an inflammatory marker that has shown promise in the prognosis of critically ill patients. This study is aimed to assess the value of CRP/albumin ratio to predict severity in acute pancreatitis. Methods: a retrospective study was performed using a prospectively collected database of patients diagnosed with AP admitted to the Department of Gastroenterology between March 2014 and December 2021. Results: among 722 patients included in the study, 78.67 % had mild, 15.65 % had moderately severe, and 5.67 % had severe acute pancreatitis. The CRP/albumin ratio was significantly associated with severe AP (OR 1.02; 95 % CI: 1.01-1.03; p < 0.001), and each ten-unit increase in the ratio was associated with a 20 % increased likelihood of severe acute pancreatitis. The area under the ROC curve (AUC) value of the CRP/albumin ratio in severe acute pancreatitis was 0.68 (95 % CI: 0.58-0.77), which was higher than that of the Ranson criteria (0.62). The optimal cut-off value for predicting severe acute pancreatitis was 7.51, with a sensitivity of 63.4 % and specificity of 65.6 %. Conclusions: despite its low sensitivity and specificity, the CRP/albumin ratio could be used as a complementary marker to the current scoring systems for the initial assessment of acute pancreatitis prognosis. It is easily obtainable and can provide additional prognostic information to clinicians.
Lay Summary
The present study investigated the potential of C-reactive protein (CRP) to albumin ratio in predicting the severity of acute pancreatitis. Data from 722 patients diagnosed with acute pancreatitis were analyzed, revealing a significant association between the CRP/albumin ratio and severe cases of the condition. Each 10-unit increase in the ratio was found to be associated with a 20% higher likelihood of developing severe pancreatitis. A comparison was made between the performance of the CRP/albumin ratio and the commonly used Ranson criteria scoring system, demonstrating that the ratio had a higher predictive value for severe acute pancreatitis. An optimal cut-off value of 7.51 was identified for the CRP/albumin ratio in identifying severe acute pancreatitis. At this threshold, the test showed a sensitivity of 63.4% and specificity of 65.6%. Despite limitations in terms of sensitivity and specificity, the CRP/albumin ratio could serve as a supplementary tool alongside existing scoring systems in the initial assessment of acute pancreatitis. Obtained easily through a blood test, the ratio provides additional prognostic information, assisting clinicians in evaluating the severity of the condition and making informed treatment decisions. Further research is required to validate these findings and evaluate the clinical utility of the CRP/albumin ratio in managing acute pancreatitis.
Share Button
New comment
Comments
No comments for this article
Related articles

Editorial

Etiological diagnosis of recurrent acute pancreatitis

DOI: 10.17235/reed.2024.10404/2024

Letter

Anemia can predict organ failure in acute pancreatitis

DOI: 10.17235/reed.2023.9700/2023

Editorial

Acute pancreatitis: an opportunity for gastroenterology hospitalists?

DOI: 10.17235/reed.2022.8573/2022

Digestive Diseases Image

Endoscopic necrosectomy – when the gastroenterologist faces his greatest nightmare.

DOI: 10.17235/reed.2021.8403/2021

Digestive Diseases Image

Wunderlich syndrome secondary to severe acute pancreatitis

DOI: 10.17235/reed.2021.8184/2021

Letter

Acute pancreatitis related to SARS-CoV-2 infection. Disclaimer

DOI: 10.17235/reed.2021.7853/2021

Letter

Pancreatic injury and acute pancreatitis in COVID-19 patients

DOI: 10.17235/reed.2021.7807/2021

Letter

Pancreatic injury in COVID-19: pathogenesis and challenges

DOI: 10.17235/reed.2020.7541/2020

Letter

SARS-CoV-2 and acute pancreatitis: a new etiological agent?

DOI: 10.17235/reed.2020.7481/2020

Review

New non-invasive biomarkers for colorectal cancer screening

DOI: 10.17235/reed.2020.7233/2020

Letter

Bortezomib-induced acute pancreatitis, an uncommon adverse event

DOI: 10.17235/reed.2020.7120/2020

Letter

Acute pancreatitis associated with levofloxacin

DOI: 10.17235/reed.2020.6652/2019

Digestive Diseases Image

Endoscopic therapy in disconnected duct syndrome: re-connecting the duct

DOI: 10.17235/reed.2020.6650/2019

Digestive Diseases Image

Colon perforation due to fistulization of a pancreatic pseudocyst

DOI: 10.17235/reed.2018.5884/2018

Digestive Diseases Image

A rare case of acute obstructive suppurative pancreatic ductitis associated with ERCP

DOI: 10.17235/reed.2018.5756/2018

Letter to the Editor

A patient with Castleman’s disease mimicking acute pancreatitis

DOI: 10.17235/reed.2017.5120/2017

Editorial

Acute-on-chronic liver failure: a time to step forward

DOI: 10.17235/reed.2017.5054/2017

Letter to the Editor

Abdominal compartment syndrome secondary to acute necrotizing pancreatitis

DOI: 10.17235/reed.2017.4810/2016

Letter to the Editor

Genetics in idiopathic pancreatitis and acute recurrent pancreatitis

DOI: 10.17235/reed.2017.4632/2016

Letter to the Editor

Intramural gastric hematoma in the context of an acute pancreatitis

DOI: 10.17235/reed.2017.4494/2016

Case Report

Acute hemorrhagic necrotizing pancreatitis in falciparum malaria

DOI: 10.17235/reed.2015.3768/2015

Citation tools
Piñerúa-Gonsálvez J, Ruiz Rebollo M, Zambrano-Infantino R, Rizzo-Rodríguez M, Fernández-Salazar L. Value of CRP/albumin ratio as a prognostic marker of acute pancreatitis: a retrospective study. 9345/2022


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1330 visits.
This article has been downloaded 252 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 10/11/2022

Accepted: 01/07/2023

Online First: 04/08/2023

Published: 12/12/2023

Article revision time: 225 days

Article Online First time: 267 days

Article editing time: 397 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology