Year 2023 / Volume 115 / Number 8
Original
Serologic response to COVID-19 vaccines in patients with inflammatory bowel disease: a prospective study

444-449

DOI: 10.17235/reed.2022.9101/2022

María Dolores Martín Arranz, Laura García-Ramírez, Eduardo Martín Arranz, Dolores Montero Vega, José Luis Rueda García, María Sánchez-Azofra, Joaquín Poza Cordón, Jesús Noci Belda, Tamara Verges Martínez-Meco, Paula Blanco San Miguel, Cristina Suárez-Ferrer,

Abstract
Background and aims: response to the SARS-CoV-2 vaccine can be altered in patients with immune-mediated diseases, such as inflammatory bowel disease, and in patients under immunosuppressive treatment. The aims of this study were to evaluate the serologic response to the SARS-CoV-2 vaccine in patients with inflammatory bowel disease, to analyze the influence of immunosuppressive drugs on response, and to describe any adverse events in this population. Methods: this was a prospective study that included adult patients with inflammatory bowel disease. Baseline characteristics, concomitant treatments and previous COVID-19 symptoms were collected. Patients underwent serological testing before the first and after the second vaccine dose. Results: a total of 265 patients were consecutively included. Patients received one of the following vaccines: messenger RNA vaccines from Pfizer/BioNTech and Moderna; and adenovirus vaccines from AstraZeneca and Janssen. All adverse events were mild, and the most frequent was injection site pain in 141 (86 %) patients. The seroconversion rate according to the treatment that patients were receiving was: 100 % for those without treatment, 92.5 % for patients treated with mesalazine, 90.3 % for those receiving immunomodulators, 88.9 % for patients with biological monotherapy and 92.5 % for patients on combined treatment. The generation of antibodies according to the vaccine administered was: Pfizer 92.9 %, Moderna 93.3 %, AstraZeneca 98.4 %, and Janssen 12.5 %. Conclusion: the antibody response after vaccination against SARS-CoV-2 is high in patients with inflammatory bowel disease. However, patients treated with immunosuppressive or biologic drugs had a lower response. Adverse events were frequent, but not serious.
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Martín Arranz M, García-Ramírez L, Martín Arranz E, Montero Vega D, Rueda García J, Sánchez-Azofra M, et all. Serologic response to COVID-19 vaccines in patients with inflammatory bowel disease: a prospective study. 9101/2022


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Publication history

Received: 28/07/2022

Accepted: 15/12/2022

Online First: 16/01/2023

Published: 26/07/2023

Article revision time: 111 days

Article Online First time: 172 days

Article editing time: 363 days


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