Year 2017 / Volume 109 / Number 6
Original
Post-transplant lymphoproliferative disease in liver transplant recipients

406-413

DOI: 10.17235/reed.2017.4228/2016

Mercedes Rubio-Manzanares Dorado, José María Álamo Martínez, Carmen Bernal Bellido, Luis Miguel Marín Gómez, Gonzalo Suárez Artacho, Carmen Cepeda Franco, Jize Wang, Miguel Ángel Gómez Bravo, Francisco Javier Padillo,

Abstract
Introduction: Post-transplant lymphoproliferative syndrome (PTLD) is a rare and potentially life-threatening complication after liver transplantation. The aim of this study was to analyze the clinicopathologic features related to PTLD in a single institution after liver transplantation. Methods: Observational study where we have retrospectively analyzed 851 cases who underwent liver transplantation. Ten cases have developed PTLD. Their clinical-pathological characteristics and the treatment received have been analyzed. Results: PTLD incidence was 1.2% (10/851). The mean time from liver transplantation to PTLD diagnosis was 36 months (range 1.2 to 144 months). PTLD localization was extranodal in all cases, the most frequent location being intestinal. Seven cases showed a monomorphic lymphoma which in all cases was differentiated B cell lymphomas. Fifty per cent of the series were seropositive for Epstein-Barr virus. Five patients were alive at the time of the review. Among these patients, we observed three cases of complete remission and two cases of disease stabilization. The death rate was higher in the first year after diagnosis of PTLD. Conclusion: PTLD is a rare complication after liver transplantation, but it may pose a threat to the life of a liver transplant recipient. It is essential to identify patients at risk, to establish an early diagnosis and treatment that can change the outcome of the disease.
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Rubio-Manzanares Dorado M, Álamo Martínez J, Bernal Bellido C, Marín Gómez L, Suárez Artacho G, Cepeda Franco C, et all. Post-transplant lymphoproliferative disease in liver transplant recipients. 4228/2016


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Publication history

Received: 26/01/2016

Accepted: 08/01/2017

Online First: 16/05/2017

Published: 01/06/2017

Article revision time: 340 days

Article Online First time: 476 days

Article editing time: 492 days


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