Year 2018 / Volume 110 / Number 11
Case Report
Treatment of graft-versus-host disease with mesenchymal cells as a complication of a liver transplantation

734-736

DOI: 10.17235/reed.2018.5672/2018

Lorena Mora, Félix Alegre, José Juan Rifón, Pablo Martí, José Ignacio Herrero,

Abstract
We present the case of a liver transplant (LT) recipient donor who developed graft versus host disease (GVHD). The main features were cutaneous rash, diarrhea and pancytopenia. Mesenchymal cells were administered as part of the treatment. This is the first case of a patient with GVHD after LT reported to date. Despite the treatment, there was no improvement in aplasia or gastrointestinal symptoms and the patient died due to a disseminated infection.
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References
1 Guo ZY, He XS, Wu LW, et al. Graft-verse-host disease after liver transplantation: A report of two cases and review of literature. World J Gastroenterol 2008;14:974-9. DOI: 10.3748/wjg.14.974.
2 Elfeki MA, Pungpapong S, Genco PV et al. Graft-versus-host disease after orthotopic liver transplantation: multivariate analysis of risk factors. Clin Transplant. 2015 Dec;29(12):1063-6. doi: 10.1111/ctr.12627.
3 Murali AR, Chandra S, Stewart Z elt al. Graft Versus Host Disease After Liver Transplantation in Adults: A Case series, Review of Literature, and an Approach to Management. Transplantation. 2016 Dec;100(12):2661-2670.
4 Pérez-Saborido B, Asensio-Díaz E, Barrera-Rebollo A et al. Graft versus host disease as a complication after liver transplantation: A rare but serious association. Rev Esp Enferm Dig. 2016 Jan;108(1):49-50.
5 Sami Akbulut, Mehmet Yilmaz, and Sezai Yilmaz. Graft-versus-host disease after liver transplantation: A comprehensive literature review. World J Gastroenterol. 2012 Oct 7; 18(37): 5240–5248.
6 Lionel Hon Wai Lum, Fei Wen Chen, Louise Jackett et al. Fever and Pancytopenia in a Liver Transplant Recipient: Going Against the Rules of Occam's Razor. Transplant Direct. 2017 Jul; 3(7): e169.
7 Sánchez-Guijo F, Caballero-Velázquez T, López-Villar O, et al. Sequential third-party mesenchymal stromal cell therapy for refractory acute graft-versus-host disease. Biol Blood Marrow Transplant. 2014 Oct; 20(10):1580-5.
8 X.Chen et al. Efficacy of Mesenchymal Stem Cell Therapy for Steroid-Refractory Acute Graft-Versus-Host Disease following Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis. PLoS ONE 10(8): e0136991. doi:10.1371/journal.pone.0136991.
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Mora L, Alegre F, Rifón J, Martí P, Herrero J. Treatment of graft-versus-host disease with mesenchymal cells as a complication of a liver transplantation. 5672/2018


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Publication history

Received: 24/04/2018

Accepted: 13/07/2018

Online First: 04/10/2018

Published: 30/10/2018

Article revision time: 77 days

Article Online First time: 163 days

Article editing time: 189 days


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